Distinctions in gastric cancer gene expression signatures derived from laser capture microdissection versus histologic macrodissection

• Published in: BMC medical genomics Vol. 4; no. 1; p. 48
• Main Authors: Kim, Hark Kyun, Kim, Joseph, Korolevich, Susie, Choi, Il Ju, Kim, Chang Hee, Munroe, David J, Green, Jeffrey E
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 02.06.2011; BioMed Central; BMC
• Subjects: Comparative Genomic Hybridization; Diagnosis; Dissection; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic aspects; Humans; Lasers; Microdissection - methods; Risk factors; RNA, Messenger - metabolism; Stomach cancer; Stomach Neoplasms - genetics; Stomach Neoplasms - pathology; United States; South Korea

Gastric cancer samples obtained by histologic macrodissection contain a relatively high stromal content that may significantly influence gene expression profiles. Differences between the gene expression signature derived from macrodissected gastric cancer samples and the signature obtained from isol...