Pembrolizumab (MK-3475) plus platinum and gemcitabine as first-line treatment of recurrent/metastatic head and neck squamous cell carcinoma (PIPER): a phase 2, multicentre, single-arm protocol study in Malaysia

• Published in: BMJ open Vol. 14; no. 12; p. e076898
• Main Authors: Cheong, Sok Ching, Selvam, Bawani, Ho, Gwo Fuang, Muhamad Nor, Ibtisam, Tan, Chih Kiang, Wong, Yoke Fui, Teo, Soo Hwang, Lim, Kue Peng, Chai, Annie Wai Yeeng, Yahya, Abqariyah, Wan Ishak, Wan Zamaniah
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 03.12.2024; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Adult; Antibodies, Monoclonal, Humanized - administration & dosage; Antibodies, Monoclonal, Humanized - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Asian people; Biomarkers; Biomedical research; Cancer; CHEMOTHERAPY; Cisplatin - administration & dosage; Cisplatin - therapeutic use; Clinical trials; Clinical Trials, Phase II as Topic; Deoxycytidine - administration & dosage; Deoxycytidine - analogs & derivatives; Deoxycytidine - therapeutic use; Female; Gemcitabine; Head & neck cancer; Head & neck tumours; Head and Neck Neoplasms - drug therapy; Head and Neck Neoplasms - pathology; Humans; IMMUNOLOGY; Immunotherapy; Informed consent; Malaysia; Male; Metastasis; Middle Aged; Monoclonal antibodies; Multicenter Studies as Topic; Neoplasm Recurrence, Local - drug therapy; Oncology; Patient safety; Pregnancy; Protocol; Response rates; Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck - drug therapy; Targeted cancer therapy; Throat cancer; Toxicity; Malaysia; CHEMOTHERAPY; Head & neck tumours; IMMUNOLOGY

IntroductionTreatment combination of pembrolizumab plus platinum and 5-fluorouracil (PF) has increased the survival of recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). The combination of platinum and gemcitabine (PG) has been shown to be superior to PF in the treatment of...