Evaluation of safety and efficacy of intracranial self-expanding drug-eluting stents for symptomatic intracranial atherosclerotic stenosis: a prospective, multicentre, randomised controlled, superiority clinical trial protocol

• Published in: BMJ open Vol. 14; no. 11; p. e091152
• Main Authors: Zhu, Zhengpeng, He, Yanyan, Zhao, Jingge, Liu, Wenbo, Ding, Qianhao, Li, Shikai, Pang, Yukuan, Zhao, Yang, Zhu, Liangfu, Wang, Ziliang, Li, Tianxiao, He, Yingkun
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 27.11.2024; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Adult; Angioplasty; Anticoagulants; Aspirin; Atherosclerosis; Blood pressure; Boron; Cell growth; China; Clinical trials; Constriction, Pathologic; Drug-Eluting Stents; Female; Humans; Hypertension; Interventional radiology; Intracranial Arteriosclerosis - surgery; Intracranial Arteriosclerosis - therapy; Ischemia; Male; Medical imaging; Medical research; Middle Aged; Multicenter Studies as Topic; Neuroradiology; Neurosurgery; Patients; Polylactic acid; Prospective Studies; Protocol; Radiology and Imaging; Randomized Controlled Trial; Risk factors; Self Expandable Metallic Stents; Smooth muscle; Stents; Stroke; SURGERY; THERAPEUTICS; Titanium alloys; Transient ischemic attack; Treatment Outcome; Veins & arteries; China; SURGERY; THERAPEUTICS; Neurosurgery; Randomized Controlled Trial; Interventional radiology; Neuroradiology

BackgroundIn-stent restenosis (ISR) is a crucial factor that affects the long-term efficacy of intracranial bare metal stent (BMS) implantation for intracranial atherosclerotic stenosis (ICAS). Patients with intracranial ISR are at a high risk of recurrent ischaemic events. The NOVA intracranial dru...