Effect of perioperative dexmedetomidine on postoperative delirium in patients with brain tumours: a protocol of a randomised controlled trial

• Published in: BMJ open Vol. 14; no. 11; p. e084380
• Main Authors: Zeng, Min, Zheng, Maoyao, Wang, Jie, Li, Shu, Ji, Nan, Peng, Yuming
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 07.11.2024; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Adult; Anaesthesia; Anaesthesia in neurology; Analgesics; Analgesics, Non-Narcotic - administration & dosage; Analgesics, Non-Narcotic - therapeutic use; Anesthesia; Brain cancer; Brain Neoplasms - surgery; Brain research; Cognitive ability; Delirium; Delirium - prevention & control; Dexmedetomidine - administration & dosage; Dexmedetomidine - therapeutic use; Emergence Delirium - epidemiology; Emergence Delirium - prevention & control; Female; Glioma; Heart rate; Humans; Hypnotics and Sedatives - administration & dosage; Hypnotics and Sedatives - therapeutic use; Intubation; Male; Middle Aged; Neurological oncology; Neurosurgery; Neurosurgical Procedures - adverse effects; Patients; Perioperative Care - methods; Postoperative Complications - prevention & control; Postoperative delirium; Protocol; Randomized Controlled Trials as Topic; Surgery; Tumors; Beijing China; China; Neurological oncology; Neurosurgery; Postoperative delirium; Anaesthesia in neurology

IntroductionNeurosurgery is a risk factor for postoperative delirium. Dexmedetomidine has a potential effect on reducing postoperative delirium. We aim to test the primary hypothesis that perioperative administration of dexmedetomidine reduces the incidence of postoperative delirium in patients unde...