Connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment-resistant moderate to severe depression: study protocol for a randomised double-blind controlled trial (BRIGhTMIND)

• Published in: BMJ open Vol. 10; no. 7; p. e038430
• Main Authors: Morriss, Richard, Webster, Lucy, Abdelghani, Mohamed, Auer, Dorothee P, Barber, Shaun, Bates, Peter, Blamire, Andrew, Briley, Paul M, Brookes, Cassandra, Iwabuchi, Sarina, James, Marilyn, Kaylor-Hughes, Catherine, Lankappa, Sudheer, Liddle, Peter, McAllister-Williams, Hamish, O'Neill-Kerr, Alex, Pszczolkowski Parraguez, Stefan, Suazo Di Paola, Ana, Thomson, Louise, Walters, Yvette
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 07.07.2020; BMJ Publishing Group
• Series: Protocol
• Subjects: Adult; Antidepressants; Cost analysis; COVID-19; Depression; Depressive Disorder, Major - therapy; Depressive Disorder, Treatment-Resistant - therapy; Double-Blind Method; Double-blind studies; Electroconvulsive therapy; Humans; Massachusetts; Mental depression; Mental disorders; Mental Health; Pregnancy; Quality of Life; Randomized Controlled Trials as Topic; Spectrum analysis; Transcranial Magnetic Stimulation; Treatment Outcome; Massachusetts; United Kingdom > UK; adult psychiatry; magnetic resonance imaging; clinical trials; depression & mood disorders; health economics

IntroductionThe BRIGhTMIND study aims to determine the clinical effectiveness, cost-effectiveness and mechanism of action of connectivity guided intermittent theta burst stimulation (cgiTBS) versus standard repetitive transcranial magnetic stimulation (rTMS) in adults with moderate to severe treatme...