Connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment-resistant moderate to severe depression: study protocol for a randomised double-blind controlled trial (BRIGhTMIND)

IntroductionThe BRIGhTMIND study aims to determine the clinical effectiveness, cost-effectiveness and mechanism of action of connectivity guided intermittent theta burst stimulation (cgiTBS) versus standard repetitive transcranial magnetic stimulation (rTMS) in adults with moderate to severe treatme...

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Published inBMJ open Vol. 10; no. 7; p. e038430
Main Authors Morriss, Richard, Webster, Lucy, Abdelghani, Mohamed, Auer, Dorothee P, Barber, Shaun, Bates, Peter, Blamire, Andrew, Briley, Paul M, Brookes, Cassandra, Iwabuchi, Sarina, James, Marilyn, Kaylor-Hughes, Catherine, Lankappa, Sudheer, Liddle, Peter, McAllister-Williams, Hamish, O'Neill-Kerr, Alex, Pszczolkowski Parraguez, Stefan, Suazo Di Paola, Ana, Thomson, Louise, Walters, Yvette
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group LTD 07.07.2020
BMJ Publishing Group
SeriesProtocol
Subjects
Adult
Antidepressants
Cost analysis
COVID-19
Depression
Depressive Disorder, Major - therapy
Depressive Disorder, Treatment-Resistant - therapy
Double-Blind Method
Double-blind studies
Electroconvulsive therapy
Humans
Massachusetts
Mental depression
Mental disorders
Mental Health
Pregnancy
Quality of Life
Randomized Controlled Trials as Topic
Spectrum analysis
Transcranial Magnetic Stimulation
Treatment Outcome
Massachusetts
United Kingdom > UK
adult psychiatry
magnetic resonance imaging
clinical trials
depression & mood disorders
health economics
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Abstract IntroductionThe BRIGhTMIND study aims to determine the clinical effectiveness, cost-effectiveness and mechanism of action of connectivity guided intermittent theta burst stimulation (cgiTBS) versus standard repetitive transcranial magnetic stimulation (rTMS) in adults with moderate to severe treatment resistant depression.Methods and analysisThe study is a randomised double-blind controlled trial with 1:1 allocation to either 20 sessions of (1) cgiTBS or (2) neuronavigated rTMS not using connectivity guidance. A total of 368 eligible participants with a diagnosis of current unipolar major depressive disorder that is both treatment resistant (defined as scoring 2 or more on the Massachusetts General Hospital Staging Score) and moderate to severe (scoring >16 on the 17-item Hamilton Depression Rating Scale (HDRS-17)), will be recruited from primary and secondary care settings at four treatment centres in the UK. The primary outcome is depression response at 16 weeks (50% or greater reduction in HDRS-17 score from baseline). Secondary outcomes include assessments of self-rated depression, anxiety, psychosocial functioning, cognition and quality of life at 8, 16 and 26 weeks postrandomisation. Cost-effectiveness, patient acceptability, safety, mechanism of action and predictors of response will also be examined.Ethics and disseminationEthical approval was granted by East Midlands Leicester Central Research Ethics Committee (ref: 18/EM/0232) on 30 August 2018. The results of the study will be published in relevant peer-reviewed journals, and then through professional and public conferences and media. Further publications will explore patient experience, moderators and mediators of outcome and mechanism of action.Trial registration numberISRCTN19674644
AbstractList Introduction The BRIGhTMIND study aims to determine the clinical effectiveness, cost-effectiveness and mechanism of action of connectivity guided intermittent theta burst stimulation (cgiTBS) versus standard repetitive transcranial magnetic stimulation (rTMS) in adults with moderate to severe treatment resistant depression.Methods and analysis The study is a randomised double-blind controlled trial with 1:1 allocation to either 20 sessions of (1) cgiTBS or (2) neuronavigated rTMS not using connectivity guidance. A total of 368 eligible participants with a diagnosis of current unipolar major depressive disorder that is both treatment resistant (defined as scoring 2 or more on the Massachusetts General Hospital Staging Score) and moderate to severe (scoring >16 on the 17-item Hamilton Depression Rating Scale (HDRS-17)), will be recruited from primary and secondary care settings at four treatment centres in the UK. The primary outcome is depression response at 16 weeks (50% or greater reduction in HDRS-17 score from baseline). Secondary outcomes include assessments of self-rated depression, anxiety, psychosocial functioning, cognition and quality of life at 8, 16 and 26 weeks postrandomisation. Cost-effectiveness, patient acceptability, safety, mechanism of action and predictors of response will also be examined.Ethics and dissemination Ethical approval was granted by East Midlands Leicester Central Research Ethics Committee (ref: 18/EM/0232) on 30 August 2018. The results of the study will be published in relevant peer-reviewed journals, and then through professional and public conferences and media. Further publications will explore patient experience, moderators and mediators of outcome and mechanism of action.Trial registration number ISRCTN19674644
IntroductionThe BRIGhTMIND study aims to determine the clinical effectiveness, cost-effectiveness and mechanism of action of connectivity guided intermittent theta burst stimulation (cgiTBS) versus standard repetitive transcranial magnetic stimulation (rTMS) in adults with moderate to severe treatment resistant depression.Methods and analysisThe study is a randomised double-blind controlled trial with 1:1 allocation to either 20 sessions of (1) cgiTBS or (2) neuronavigated rTMS not using connectivity guidance. A total of 368 eligible participants with a diagnosis of current unipolar major depressive disorder that is both treatment resistant (defined as scoring 2 or more on the Massachusetts General Hospital Staging Score) and moderate to severe (scoring >16 on the 17-item Hamilton Depression Rating Scale (HDRS-17)), will be recruited from primary and secondary care settings at four treatment centres in the UK. The primary outcome is depression response at 16 weeks (50% or greater reduction in HDRS-17 score from baseline). Secondary outcomes include assessments of self-rated depression, anxiety, psychosocial functioning, cognition and quality of life at 8, 16 and 26 weeks postrandomisation. Cost-effectiveness, patient acceptability, safety, mechanism of action and predictors of response will also be examined.Ethics and disseminationEthical approval was granted by East Midlands Leicester Central Research Ethics Committee (ref: 18/EM/0232) on 30 August 2018. The results of the study will be published in relevant peer-reviewed journals, and then through professional and public conferences and media. Further publications will explore patient experience, moderators and mediators of outcome and mechanism of action.Trial registration numberISRCTN19674644
The BRIGhTMIND study aims to determine the clinical effectiveness, cost-effectiveness and mechanism of action of connectivity guided intermittent theta burst stimulation (cgiTBS) versus standard repetitive transcranial magnetic stimulation (rTMS) in adults with moderate to severe treatment resistant depression. The study is a randomised double-blind controlled trial with 1:1 allocation to either 20 sessions of (1) cgiTBS or (2) neuronavigated rTMS not using connectivity guidance. A total of 368 eligible participants with a diagnosis of current unipolar major depressive disorder that is both treatment resistant (defined as scoring 2 or more on the Massachusetts General Hospital Staging Score) and moderate to severe (scoring 16 on the 17-item Hamilton Depression Rating Scale (HDRS-17)), will be recruited from primary and secondary care settings at four treatment centres in the UK. The primary outcome is depression response at 16 weeks (50% or greater reduction in HDRS-17 score from baseline). Secondary outcomes include assessments of self-rated depression, anxiety, psychosocial functioning, cognition and quality of life at 8, 16 and 26 weeks postrandomisation. Cost-effectiveness, patient acceptability, safety, mechanism of action and predictors of response will also be examined. Ethical approval was granted by East Midlands Leicester Central Research Ethics Committee (ref: 18/EM/0232) on 30 August 2018. The results of the study will be published in relevant peer-reviewed journals, and then through professional and public conferences and media. Further publications will explore patient experience, moderators and mediators of outcome and mechanism of action. ISRCTN19674644.
INTRODUCTIONThe BRIGhTMIND study aims to determine the clinical effectiveness, cost-effectiveness and mechanism of action of connectivity guided intermittent theta burst stimulation (cgiTBS) versus standard repetitive transcranial magnetic stimulation (rTMS) in adults with moderate to severe treatment resistant depression. METHODS AND ANALYSISThe study is a randomised double-blind controlled trial with 1:1 allocation to either 20 sessions of (1) cgiTBS or (2) neuronavigated rTMS not using connectivity guidance. A total of 368 eligible participants with a diagnosis of current unipolar major depressive disorder that is both treatment resistant (defined as scoring 2 or more on the Massachusetts General Hospital Staging Score) and moderate to severe (scoring >16 on the 17-item Hamilton Depression Rating Scale (HDRS-17)), will be recruited from primary and secondary care settings at four treatment centres in the UK. The primary outcome is depression response at 16 weeks (50% or greater reduction in HDRS-17 score from baseline). Secondary outcomes include assessments of self-rated depression, anxiety, psychosocial functioning, cognition and quality of life at 8, 16 and 26 weeks postrandomisation. Cost-effectiveness, patient acceptability, safety, mechanism of action and predictors of response will also be examined. ETHICS AND DISSEMINATIONEthical approval was granted by East Midlands Leicester Central Research Ethics Committee (ref: 18/EM/0232) on 30 August 2018. The results of the study will be published in relevant peer-reviewed journals, and then through professional and public conferences and media. Further publications will explore patient experience, moderators and mediators of outcome and mechanism of action. TRIAL REGISTRATION NUMBERISRCTN19674644.
Author Liddle, Peter
Pszczolkowski Parraguez, Stefan
McAllister-Williams, Hamish
Brookes, Cassandra
O'Neill-Kerr, Alex
Auer, Dorothee P
Briley, Paul M
Walters, Yvette
Iwabuchi, Sarina
Morriss, Richard
Lankappa, Sudheer
Suazo Di Paola, Ana
Bates, Peter
Barber, Shaun
Kaylor-Hughes, Catherine
Webster, Lucy
Blamire, Andrew
Abdelghani, Mohamed
Thomson, Louise
James, Marilyn
AuthorAffiliation 10 Leicester Clinical Trials Unit , University of Leicester , Leicester , UK
1 Psychiatry , University of Nottingham , Nottingham , UK
12 Northamptonshire Healthcare NHS Foundation Trust , Kettering , Northamptonshire , UK
6 University of Leicester , Leicester , Leicestershire , UK
8 University of Newcastle upon Tyne , Newcastle upon Tyne , Tyne and Wear , UK
11 School of Medicine , University of Nottingham , nottingham , UK
9 University of Nottingham , Nottingham , Nottinghamshire , UK
13 Precision Imaging Beacon , University of Nottingham , Nottingham , UK
5 Sir Peter Mansfield Imaging Centre , University of Nottingham , Nottingham , UK
3 Camden and Islington NHS Foundation Trust , London , London , UK
4 Arthritis Research UK Pain Centre , University of Nottingham , Nottingham , Nottinghamshire , UK
2 Nottinghamshire Healthcare NHS Foundation Trust , Nottingham , Nottingham , UK
7 Nottingham , UK
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/32641367$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1001/jamapsychiatry.2013.143
10.1016/j.neubiorev.2015.07.014
10.1073/pnas.1000446107
10.1097/YCT.0b013e318157ac58
10.1176/jnp.9.3.471
10.1016/j.neuroimage.2016.09.043
10.1007/s12325-009-0013-x
10.1093/brain/awu109
10.4088/PCC.08m00670
10.1046/j.1525-1497.2001.016009606.x
10.1016/j.jval.2012.02.008
10.1016/j.neuroimage.2012.10.082
10.1016/j.brainres.2014.10.034
10.1016/S0140-6736(18)30295-2
10.1016/j.biopsych.2014.01.023
10.1097/YIC.0b013e3282f948f5
10.1146/annurev-publhealth-031912-114409
10.1016/j.jpsychires.2017.02.015
10.1016/S0006-3223(02)01866-8
10.1016/j.brs.2016.02.011
10.1177/070674371405900702
10.1176/ajp.151.8.1132
10.1002/hec.678
10.1016/j.euroneuro.2014.08.005
10.1038/nm.4246
10.1016/j.jad.2013.04.028
10.1016/S2215-0366(15)00436-8
10.1016/S0006-3223(03)00231-2
10.1016/j.euroneuro.2019.02.012
10.1001/archinte.166.10.1092
10.1176/ajp.2006.163.11.1905
10.1192/bjp.180.5.461
10.1176/appi.books.9780890425596
10.1176/appi.ajp.163.11.1905
10.1037/t00742-000
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Copyright Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
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Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. 2020
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– notice: 2020 Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Keywords adult psychiatry
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health economics
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References Larson, Munkácsy, Theta-burst 2015; 1621
Drysdale, Grosenick, Downar 2017; 23
Mundt, Marks, Shear 2002; 180
Simpson, Welch, Kozel 2009; 26
Rush, Trivedi, Ibrahim 2003; 54
Iwabuchi, Raschke, Auer 2017; 146
Mayberg 1997; 9
Kessler, Bromet 2013; 34
Mulders, van Eijndhoven, Schene 2015; 56
Bernstein, Fink, Handelsman 1994; 151
Lan, Chhetry, Liston 2016; 9
Iwabuchi, Auer, Lankappa 2019; 29
Blumberger, Vila-Rodriguez, Thorpe 2018; 391
Fava 2003; 53
Rush, Trivedi, Wisniewski 2006; 163
2016; 16
McGrath, Kelley, Holtzheimer 2013; 70
Kroenke, Spitzer, Williams 2001; 16
McAllister-Williams, Anderson, Finkelmeyer 2016; 3
Li, Chen, Juan 2014; 137
Berlim, McGirr, Rodrigues Dos Santos 2017; 90
Williams, Kobak, Bech 2008; 23
Demyttenaere, Desaiah, Petit 2009; 11
Spitzer, Kroenke, Williams 2006; 166
Zimmerman, Martinez, Young 2013; 150
Liston, Chen, Zebley 2014; 76
Sheline, Price, Yan 2010; 107
van Hout, Janssen, Feng 2012; 15
Rizvi, Grima, Tan 2014; 59
Iwabuchi, Peng, Fang 2014; 24
Khalid, Atkins, Tredget 2008; 24
Hoch, Briggs, Willan 2002; 11
Fox, Liu, Pascual-Leone 2013; 66
2020070802151348000_10.7.e038430.25
2020070802151348000_10.7.e038430.26
2020070802151348000_10.7.e038430.27
2020070802151348000_10.7.e038430.28
2020070802151348000_10.7.e038430.1
2020070802151348000_10.7.e038430.29
2020070802151348000_10.7.e038430.2
2020070802151348000_10.7.e038430.3
2020070802151348000_10.7.e038430.4
(2020070802151348000_10.7.e038430.6) 2016; 16
2020070802151348000_10.7.e038430.7
McGrath (2020070802151348000_10.7.e038430.19) 2013; 70
2020070802151348000_10.7.e038430.8
Demyttenaere (2020070802151348000_10.7.e038430.36) 2009; 11
2020070802151348000_10.7.e038430.9
McAllister-Williams (2020070802151348000_10.7.e038430.38) 2016; 3
Iwabuchi (2020070802151348000_10.7.e038430.22) 2017; 146
2020070802151348000_10.7.e038430.40
2020070802151348000_10.7.e038430.20
2020070802151348000_10.7.e038430.23
Khalid (2020070802151348000_10.7.e038430.5) 2008; 24
2020070802151348000_10.7.e038430.24
2020070802151348000_10.7.e038430.14
2020070802151348000_10.7.e038430.15
2020070802151348000_10.7.e038430.37
2020070802151348000_10.7.e038430.16
2020070802151348000_10.7.e038430.17
2020070802151348000_10.7.e038430.39
Iwabuchi (2020070802151348000_10.7.e038430.21) 2019; 29
2020070802151348000_10.7.e038430.30
2020070802151348000_10.7.e038430.31
2020070802151348000_10.7.e038430.10
2020070802151348000_10.7.e038430.32
2020070802151348000_10.7.e038430.11
Lan (2020070802151348000_10.7.e038430.18) 2016; 9
2020070802151348000_10.7.e038430.33
2020070802151348000_10.7.e038430.12
2020070802151348000_10.7.e038430.34
2020070802151348000_10.7.e038430.13
2020070802151348000_10.7.e038430.35
References_xml – volume: 70
  start-page: 821
  year: 2013
  article-title: Toward a neuroimaging treatment selection biomarker for major depressive disorder
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2013.143
  contributor:
    fullname: Holtzheimer
– volume: 56
  start-page: 330
  year: 2015
  article-title: Resting-state functional connectivity in major depressive disorder: a review
  publication-title: Neurosci Biobehav Rev
  doi: 10.1016/j.neubiorev.2015.07.014
  contributor:
    fullname: Schene
– volume: 107
  start-page: 11020
  year: 2010
  article-title: Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1000446107
  contributor:
    fullname: Yan
– volume: 24
  start-page: 141
  year: 2008
  article-title: The effectiveness of electroconvulsive therapy in treatment-resistant depression: a naturalistic study
  publication-title: J Ect
  doi: 10.1097/YCT.0b013e318157ac58
  contributor:
    fullname: Tredget
– volume: 9
  start-page: 471
  year: 1997
  article-title: Limbic-cortical dysregulation: a proposed model of depression
  publication-title: J Neuropsychiatry Clin Neurosci
  doi: 10.1176/jnp.9.3.471
  contributor:
    fullname: Mayberg
– volume: 146
  start-page: 395
  year: 2017
  article-title: Targeted transcranial theta-burst stimulation alters fronto-insular network and prefrontal GABA
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2016.09.043
  contributor:
    fullname: Auer
– volume: 26
  start-page: 346
  year: 2009
  article-title: Cost-effectiveness of transcranial magnetic stimulation in the treatment of major depression: a health economics analysis
  publication-title: Adv Ther
  doi: 10.1007/s12325-009-0013-x
  contributor:
    fullname: Kozel
– volume: 137
  start-page: 2088
  year: 2014
  article-title: Efficacy of prefrontal theta-burst stimulation in refractory depression: a randomized sham-controlled study
  publication-title: Brain
  doi: 10.1093/brain/awu109
  contributor:
    fullname: Juan
– volume: 11
  start-page: 08
  year: 2009
  article-title: Patient-assessed versus physician-assessed disease severity and outcome in patients with nonspecific pain associated with major depressive disorder
  publication-title: Prim Care Companion J Clin Psychiatry
  doi: 10.4088/PCC.08m00670
  contributor:
    fullname: Petit
– volume: 16
  start-page: 606
  year: 2001
  article-title: The PHQ-9: validity of a brief depression severity measure
  publication-title: J Gen Intern Med
  doi: 10.1046/j.1525-1497.2001.016009606.x
  contributor:
    fullname: Williams
– volume: 15
  start-page: 708
  year: 2012
  article-title: Interim scoring for the EQ-5D-5L: mapping the EQ-5D-5L to EQ-5D-3L value sets
  publication-title: Value Health
  doi: 10.1016/j.jval.2012.02.008
  contributor:
    fullname: Feng
– volume: 66
  start-page: 151
  year: 2013
  article-title: Identification of reproducible individualized targets for treatment of depression with TMS based on intrinsic connectivity
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2012.10.082
  contributor:
    fullname: Pascual-Leone
– volume: 1621
  start-page: 38
  year: 2015
  article-title: Theta-burst LTP
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2014.10.034
  contributor:
    fullname: Theta-burst
– volume: 391
  start-page: 1683
  year: 2018
  article-title: Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(18)30295-2
  contributor:
    fullname: Thorpe
– volume: 76
  start-page: 517
  year: 2014
  article-title: Default mode network mechanisms of transcranial magnetic stimulation in depression
  publication-title: Biol Psychiatry
  doi: 10.1016/j.biopsych.2014.01.023
  contributor:
    fullname: Zebley
– volume: 23
  start-page: 120
  year: 2008
  article-title: The GRID-HAMD: standardization of the Hamilton depression rating scale
  publication-title: Int Clin Psychopharmacol
  doi: 10.1097/YIC.0b013e3282f948f5
  contributor:
    fullname: Bech
– volume: 34
  start-page: 119
  year: 2013
  article-title: The epidemiology of depression across cultures
  publication-title: Annu Rev Public Health
  doi: 10.1146/annurev-publhealth-031912-114409
  contributor:
    fullname: Bromet
– volume: 90
  start-page: 102
  year: 2017
  article-title: Efficacy of theta burst stimulation (tbs) for major depression: an exploratory meta-analysis of randomized and sham-controlled trials
  publication-title: J Psychiatr Res
  doi: 10.1016/j.jpsychires.2017.02.015
  contributor:
    fullname: Rodrigues Dos Santos
– volume: 54
  start-page: 573
  year: 2003
  article-title: The 16-Item quick inventory of depressive symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression
  publication-title: Biol Psychiatry
  doi: 10.1016/S0006-3223(02)01866-8
  contributor:
    fullname: Ibrahim
– volume: 9
  start-page: 577
  year: 2016
  article-title: Transcranial magnetic stimulation of left dorsolateral prefrontal cortex induces brain morphological changes in regions associated with a treatment resistant major depressive episode: an exploratory analysis
  publication-title: Brain Stimul
  doi: 10.1016/j.brs.2016.02.011
  contributor:
    fullname: Liston
– volume: 59
  start-page: 349
  year: 2014
  article-title: Treatment-resistant depression in primary care across Canada
  publication-title: Can J Psychiatry
  doi: 10.1177/070674371405900702
  contributor:
    fullname: Tan
– volume: 151
  start-page: 1132
  year: 1994
  article-title: Initial reliability and validity of a new retrospective measure of child abuse and neglect
  publication-title: Am J Psychiatry
  doi: 10.1176/ajp.151.8.1132
  contributor:
    fullname: Handelsman
– volume: 11
  start-page: 415
  year: 2002
  article-title: Something old, something new, something borrowed, something blue: a framework for the marriage of health econometrics and cost-effectiveness analysis
  publication-title: Health Econ
  doi: 10.1002/hec.678
  contributor:
    fullname: Willan
– volume: 24
  start-page: 1784
  year: 2014
  article-title: Alterations in effective connectivity anchored on the insula in major depressive disorder
  publication-title: Eur Neuropsychopharmacol
  doi: 10.1016/j.euroneuro.2014.08.005
  contributor:
    fullname: Fang
– volume: 23
  start-page: 28
  year: 2017
  article-title: Resting-state connectivity biomarkers define neurophysiological subtypes of depression
  publication-title: Nat Med
  doi: 10.1038/nm.4246
  contributor:
    fullname: Downar
– volume: 150
  start-page: 384
  year: 2013
  article-title: Severity classification on the Hamilton depression rating scale
  publication-title: J Affect Disord
  doi: 10.1016/j.jad.2013.04.028
  contributor:
    fullname: Young
– volume: 3
  start-page: 117
  year: 2016
  article-title: Antidepressant augmentation with metyrapone for treatment-resistant depression (the add study): a double-blind, randomised, placebo-controlled trial
  publication-title: Lancet Psychiatry
  doi: 10.1016/S2215-0366(15)00436-8
  contributor:
    fullname: Finkelmeyer
– volume: 53
  start-page: 649
  year: 2003
  article-title: Diagnosis and definition of treatment-resistant depression
  publication-title: Biol Psychiatry
  doi: 10.1016/S0006-3223(03)00231-2
  contributor:
    fullname: Fava
– volume: 29
  start-page: 681
  year: 2019
  article-title: Baseline effective connectivity predicts response to repetitive transcranial magnetic stimulation in patients with treatment-resistant depression
  publication-title: Eur Neuropsychopharmacol
  doi: 10.1016/j.euroneuro.2019.02.012
  contributor:
    fullname: Lankappa
– volume: 166
  start-page: 1092
  year: 2006
  article-title: A brief measure for assessing generalized anxiety disorder: the GAD-7
  publication-title: Arch Intern Med
  doi: 10.1001/archinte.166.10.1092
  contributor:
    fullname: Williams
– volume: 163
  start-page: 1905
  year: 2006
  article-title: Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report
  publication-title: Am J Psychiatry
  doi: 10.1176/ajp.2006.163.11.1905
  contributor:
    fullname: Wisniewski
– volume: 16
  start-page: 1
  year: 2016
  article-title: Repetitive transcranial magnetic stimulation for treatment-resistant depression: a systematic review and meta-analysis of randomized controlled trials
  publication-title: Ont Health Technol Assess Ser
– volume: 180
  start-page: 461
  year: 2002
  article-title: The work and social adjustment scale: a simple measure of impairment in functioning
  publication-title: Br J Psychiatry
  doi: 10.1192/bjp.180.5.461
  contributor:
    fullname: Shear
– ident: 2020070802151348000_10.7.e038430.30
  doi: 10.1046/j.1525-1497.2001.016009606.x
– volume: 70
  start-page: 821
  year: 2013
  ident: 2020070802151348000_10.7.e038430.19
  article-title: Toward a neuroimaging treatment selection biomarker for major depressive disorder
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2013.143
  contributor:
    fullname: McGrath
– ident: 2020070802151348000_10.7.e038430.9
  doi: 10.1016/j.brainres.2014.10.034
– volume: 29
  start-page: 681
  year: 2019
  ident: 2020070802151348000_10.7.e038430.21
  article-title: Baseline effective connectivity predicts response to repetitive transcranial magnetic stimulation in patients with treatment-resistant depression
  publication-title: Eur Neuropsychopharmacol
  doi: 10.1016/j.euroneuro.2019.02.012
  contributor:
    fullname: Iwabuchi
– ident: 2020070802151348000_10.7.e038430.26
  doi: 10.1016/S0006-3223(03)00231-2
– ident: 2020070802151348000_10.7.e038430.17
  doi: 10.1016/j.neubiorev.2015.07.014
– ident: 2020070802151348000_10.7.e038430.14
  doi: 10.1016/j.euroneuro.2014.08.005
– ident: 2020070802151348000_10.7.e038430.7
  doi: 10.1007/s12325-009-0013-x
– ident: 2020070802151348000_10.7.e038430.28
  doi: 10.1176/ajp.151.8.1132
– ident: 2020070802151348000_10.7.e038430.25
  doi: 10.1176/appi.books.9780890425596
– ident: 2020070802151348000_10.7.e038430.27
  doi: 10.1097/YIC.0b013e3282f948f5
– ident: 2020070802151348000_10.7.e038430.3
  doi: 10.1176/appi.ajp.163.11.1905
– ident: 2020070802151348000_10.7.e038430.39
– ident: 2020070802151348000_10.7.e038430.33
  doi: 10.1016/j.jval.2012.02.008
– volume: 24
  start-page: 141
  year: 2008
  ident: 2020070802151348000_10.7.e038430.5
  article-title: The effectiveness of electroconvulsive therapy in treatment-resistant depression: a naturalistic study
  publication-title: J Ect
  doi: 10.1097/YCT.0b013e318157ac58
  contributor:
    fullname: Khalid
– ident: 2020070802151348000_10.7.e038430.40
  doi: 10.1002/hec.678
– ident: 2020070802151348000_10.7.e038430.4
  doi: 10.1177/070674371405900702
– ident: 2020070802151348000_10.7.e038430.20
  doi: 10.1038/nm.4246
– ident: 2020070802151348000_10.7.e038430.35
– ident: 2020070802151348000_10.7.e038430.29
  doi: 10.1037/t00742-000
– volume: 9
  start-page: 577
  year: 2016
  ident: 2020070802151348000_10.7.e038430.18
  article-title: Transcranial magnetic stimulation of left dorsolateral prefrontal cortex induces brain morphological changes in regions associated with a treatment resistant major depressive episode: an exploratory analysis
  publication-title: Brain Stimul
  doi: 10.1016/j.brs.2016.02.011
  contributor:
    fullname: Lan
– ident: 2020070802151348000_10.7.e038430.13
  doi: 10.1016/j.neuroimage.2012.10.082
– ident: 2020070802151348000_10.7.e038430.23
  doi: 10.1016/j.biopsych.2014.01.023
– ident: 2020070802151348000_10.7.e038430.12
  doi: 10.1016/S0140-6736(18)30295-2
– ident: 2020070802151348000_10.7.e038430.10
  doi: 10.1016/j.jpsychires.2017.02.015
– ident: 2020070802151348000_10.7.e038430.32
  doi: 10.1192/bjp.180.5.461
– ident: 2020070802151348000_10.7.e038430.24
– ident: 2020070802151348000_10.7.e038430.11
  doi: 10.1093/brain/awu109
– ident: 2020070802151348000_10.7.e038430.16
  doi: 10.1073/pnas.1000446107
– ident: 2020070802151348000_10.7.e038430.31
  doi: 10.1001/archinte.166.10.1092
– ident: 2020070802151348000_10.7.e038430.1
  doi: 10.1146/annurev-publhealth-031912-114409
– ident: 2020070802151348000_10.7.e038430.37
  doi: 10.1016/j.jad.2013.04.028
– volume: 16
  start-page: 1
  year: 2016
  ident: 2020070802151348000_10.7.e038430.6
  article-title: Repetitive transcranial magnetic stimulation for treatment-resistant depression: a systematic review and meta-analysis of randomized controlled trials
  publication-title: Ont Health Technol Assess Ser
– ident: 2020070802151348000_10.7.e038430.8
– ident: 2020070802151348000_10.7.e038430.15
  doi: 10.1176/jnp.9.3.471
– volume: 3
  start-page: 117
  year: 2016
  ident: 2020070802151348000_10.7.e038430.38
  article-title: Antidepressant augmentation with metyrapone for treatment-resistant depression (the add study): a double-blind, randomised, placebo-controlled trial
  publication-title: Lancet Psychiatry
  doi: 10.1016/S2215-0366(15)00436-8
  contributor:
    fullname: McAllister-Williams
– volume: 146
  start-page: 395
  year: 2017
  ident: 2020070802151348000_10.7.e038430.22
  article-title: Targeted transcranial theta-burst stimulation alters fronto-insular network and prefrontal GABA
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2016.09.043
  contributor:
    fullname: Iwabuchi
– ident: 2020070802151348000_10.7.e038430.2
– ident: 2020070802151348000_10.7.e038430.34
  doi: 10.1016/S0006-3223(02)01866-8
– volume: 11
  start-page: 08
  year: 2009
  ident: 2020070802151348000_10.7.e038430.36
  article-title: Patient-assessed versus physician-assessed disease severity and outcome in patients with nonspecific pain associated with major depressive disorder
  publication-title: Prim Care Companion J Clin Psychiatry
  doi: 10.4088/PCC.08m00670
  contributor:
    fullname: Demyttenaere
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Snippet IntroductionThe BRIGhTMIND study aims to determine the clinical effectiveness, cost-effectiveness and mechanism of action of connectivity guided intermittent...
The BRIGhTMIND study aims to determine the clinical effectiveness, cost-effectiveness and mechanism of action of connectivity guided intermittent theta burst...
INTRODUCTIONThe BRIGhTMIND study aims to determine the clinical effectiveness, cost-effectiveness and mechanism of action of connectivity guided intermittent...
Introduction The BRIGhTMIND study aims to determine the clinical effectiveness, cost-effectiveness and mechanism of action of connectivity guided intermittent...
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StartPage e038430
SubjectTerms Adult
Antidepressants
Cost analysis
COVID-19
Depression
Depressive Disorder, Major - therapy
Depressive Disorder, Treatment-Resistant - therapy
Double-Blind Method
Double-blind studies
Electroconvulsive therapy
Humans
Massachusetts
Mental depression
Mental disorders
Mental Health
Pregnancy
Quality of Life
Randomized Controlled Trials as Topic
Spectrum analysis
Transcranial Magnetic Stimulation
Treatment Outcome
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Title Connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment-resistant moderate to severe depression: study protocol for a randomised double-blind controlled trial (BRIGhTMIND)
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