Nature of T cell epitopes in lupus antigens and HLA-DR determines autoantibody initiation and diversification

• Published in: Annals of the rheumatic diseases Vol. 78; no. 3; pp. 380 - 390
• Main Authors: Zhao, Zhenhuan, Ren, Jiling, Dai, Chao, Kannapell, Carol C, Wang, Hongyang, Gaskin, Felicia, Fu, Shu Man
• Format: Journal Article
• Language: English
• Published: England Elsevier Limited 01.03.2019
• Subjects: Animals; Antigens; Arthritis; Autoantibodies; Autoantibodies - immunology; Autoantigens; Autoantigens - immunology; Autoimmune diseases; Autoimmunity; Autoimmunity - immunology; Bacteria; Bioinformatics; Blood donors; Clonal selection; Cross Reactions - immunology; Diabetes; Disease; Disease Models, Animal; Diversification; Enzyme-linked immunosorbent assay; Epitopes; Epitopes, T-Lymphocyte - immunology; Histocompatibility antigen HLA; HLA-DR Antigens - immunology; Immunohistochemistry; Lupus; Lupus Erythematosus, Systemic - immunology; Lymphatic system; Lymphocytes; Lymphocytes B; Lymphocytes T; Mice; Negative selection; Peptides; Production capacity; Proteins; Ribonucleoproteins (small nuclear); snRNP Core Proteins - immunology; Systematic review; Systemic lupus erythematosus; Transgenic animals; United States > US; Virginia; molecular mimicry; autoantibody; HLA-DR; T cell epitopes; SLE

ObjectivesThe generation of systemic lupus erythematosus (SLE)-related autoantibodies have been shown to be T cell dependent and antigen driven with HLA-DR restriction. In this study, the initiating antigen(s) and the mechanism of autoantibody diversification were investigated.MethodsT cell epitopes...