The dynamic yin-yang interaction of CXCR4 and CXCR7 in breast cancer metastasis

• Published in: Breast cancer research : BCR Vol. 14; no. 1; p. 103
• Main Authors: Hawkins, Oriana E, Richmond, Ann
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.01.2012; BioMed Central
• Subjects: Animals; Breast cancer; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer metastasis; Comparative analysis; Female; Humans; Parenting; Receptors, CXCR - metabolism; Receptors, CXCR4 - metabolism

The contribution of CXCR7 to the tumor microenvironment has introduced a new level of complexity to CXCL12 signaling in breast cancer. In the previous issue of Breast Cancer Research, Hernandez and colleagues delineate the roles of CXCR4 and CXCR7 in tumor invasion and metastasis. The authors demons...