The dynamic yin-yang interaction of CXCR4 and CXCR7 in breast cancer metastasis
The contribution of CXCR7 to the tumor microenvironment has introduced a new level of complexity to CXCL12 signaling in breast cancer. In the previous issue of Breast Cancer Research, Hernandez and colleagues delineate the roles of CXCR4 and CXCR7 in tumor invasion and metastasis. The authors demons...
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| Published in | Breast cancer research : BCR Vol. 14; no. 1; p. 103 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
BioMed Central Ltd
26.01.2012
BioMed Central |
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| Abstract | The contribution of CXCR7 to the tumor microenvironment has introduced a new level of complexity to CXCL12 signaling in breast cancer. In the previous issue of Breast Cancer Research, Hernandez and colleagues delineate the roles of CXCR4 and CXCR7 in tumor invasion and metastasis. The authors demonstrate that co-expression of CXCR7 and CXCR4 results in inhibition of CXCL12-mediated invasion, reduced intravasation of tumor cells into the vasculature, and fewer lung metastases compared with parental tumors. The results of this study suggest the combination of small molecule inhibitors of CXCR4 and CXCR7 could dramatically reduce invasion, intravasation, and metastasis and could be highly beneficial for the treatment of invasive breast cancer. |
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| AbstractList | The contribution of CXCR7 to the tumor microenvironment has introduced a new level of complexity to CXCL12 signaling in breast cancer. In the previous issue of Breast Cancer Research, Hernandez and colleagues delineate the roles of CXCR4 and CXCR7 in tumor invasion and metastasis. The authors demonstrate that co-expression of CXCR7 and CXCR4 results in inhibition of CXCL12-mediated invasion, reduced intravasation of tumor cells into the vasculature, and fewer lung metastases compared with parental tumors. The results of this study suggest the combination of small molecule inhibitors of CXCR4 and CXCR7 could dramatically reduce invasion, intravasation, and metastasis and could be highly beneficial for the treatment of invasive breast cancer. The contribution of CXCR7 to the tumor microenvironment has introduced a new level of complexity to CXCL12 signaling in breast cancer. In the previous issue of Breast Cancer Research , Hernandez and colleagues delineate the roles of CXCR4 and CXCR7 in tumor invasion and metastasis. The authors demonstrate that co-expression of CXCR7 and CXCR4 results in inhibition of CXCL12-mediated invasion, reduced intravasation of tumor cells into the vasculature, and fewer lung metastases compared with parental tumors. The results of this study suggest the combination of small molecule inhibitors of CXCR4 and CXCR7 could dramatically reduce invasion, intravasation, and metastasis and could be highly beneficial for the treatment of invasive breast cancer. |
| ArticleNumber | 103 |
| Audience | Academic |
| Author | Richmond, Ann Hawkins, Oriana E |
| AuthorAffiliation | 1 Department of Cancer Biology, Vanderbilt University School of Medicine, US Department of Veterans Affairs, 2220 Pierce Avenue, 771 Preston Research Building, Nashville, TN 37232-6840, USA |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22293321$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1074/jbc.M111.277038 10.1096/fj.05-4554fje 10.4049/jimmunol.0900269 10.1186/1476-4598-10-73 10.1182/blood-2008-12-196618 10.1186/bcr3074 10.1073/pnas.1101133108 |
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| References | 22152016 - Breast Cancer Res. 2011;13(6):R128 A Levoye (2882_CR5) 2009; 113 BA Zabel (2882_CR8) 2009; 183 FM Decaillot (2882_CR4) 2011; 286 A Shukla (2882_CR6) 2006; 20 L Hernandez (2882_CR1) 2011; 13 P Ray (2882_CR2) 2011 LJ Drury (2882_CR3) 2011; 108 BA Zabel (2882_CR7) 2011; 10 |
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| SubjectTerms | Animals Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer metastasis Comparative analysis Female Humans Parenting Receptors, CXCR - metabolism Receptors, CXCR4 - metabolism |
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| Title | The dynamic yin-yang interaction of CXCR4 and CXCR7 in breast cancer metastasis |
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