Structure and ligand-based design of P-glycoprotein inhibitors: a historical perspective

• Published in: Current pharmaceutical design Vol. 18; no. 27; p. 4197
• Main Authors: Palmeira, Andreia, Sousa, Emilia, Vasconcelos, M Helena, Pinto, Madalena, Fernandes, Miguel X
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 2012
• Subjects: Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors; ATP Binding Cassette Transporter, Subfamily B, Member 1 - chemistry; Computer-Aided Design; Crystallography; Drug Design; Drug Discovery; Drug Resistance, Neoplasm; Humans; Ligands; Mice; Neoplasms - drug therapy; Neoplasms - pathology; Quantitative Structure-Activity Relationship

Computer-assisted drug design (CADD) is a valuable approach for the discovery of new chemical entities in the field of cancer therapy. There is a pressing need to design and develop new, selective, and safe drugs for the treatment of multidrug resistance (MDR) cancer forms, specifically active again...