Upregulation of enteric alpha-synuclein as a possible link between inflammatory bowel disease and Parkinson’s disease

• Published in: Gut Vol. 70; no. 10; pp. 2010 - 2012
• Main Authors: Derkinderen, Pascal, Noble, Wendy, Neunlist, Michel, Rolli-Derkinderen, Malvyne
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.10.2021; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: alpha-Synuclein - metabolism; Axons; Biochemistry, Molecular Biology; Biopsy; Brain research; Colon; Crohn's disease; Digestive system; Enteric nervous system; Enteric Nervous System - metabolism; Ethics; Gastrointestinal tract; Genomics; Human health and pathology; Humans; Hypotheses; Hépatology and Gastroenterology; Inflammation; INFLAMMATORY BOWEL DISEASE; Inflammatory Bowel Diseases; Innervation; Intestine; Life Sciences; Movement disorders; Myenteric plexus; Neurobiology; Neurodegenerative diseases; NEUROGASTROENTEROLOGY; Neurons and Cognition; Parkinson Disease; Parkinson's disease; Pathogenesis; Pathology; Patients; PostScript; Proteins; Synuclein; Transcription; Up-Regulation; Vagus nerve; France; NEUROGASTROENTEROLOGY; INFLAMMATORY BOWEL DISEASE; alpha-synuclein; Parkinson’s disease; inflammatory bowel disease
• ISSN: 0017-5749; 1468-3288; 1468-3288
• DOI: 10.1136/gutjnl-2020-323482

In this context, they briefly discuss the possible role of alpha-synuclein, a neuronal protein which is not only expressed in both the gut and brain but that is also a key component of Parkinson’s disease pathology.2 They summarise their literature analysis by saying that ‘Expression of α-synuclein...