Clinical evaluation of the novel digital liquid chip method for anti-dsDNA detection in SLE

• Published in: Lupus science & medicine Vol. 12; no. 2; p. e001608
• Main Authors: Bai, Yina, Yu, Rui, Xue, Chiyuan, Wang, Qian, Tian, Xinping, Zeng, Xiaofeng, Li, Mengtao, Hu, Chaojun
• Format: Journal Article
• Language: English
• Published: England Lupus Foundation of America 15.07.2025; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Adult; Agreements; Antibodies; Antibodies, Antinuclear - blood; Antigens; Autoantibodies; Autoimmune Diseases; Automation; Bar codes; Biomarker Studies; Classification; Demographics; Disease; DNA - immunology; Female; Fluorescent Antibody Technique, Indirect - methods; Humans; Immunoassay; Immunoassay - methods; Laboratories; Luminescent Measurements - methods; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - diagnosis; Lupus Erythematosus, Systemic - immunology; Male; Methods; Middle Aged; Original Research; Patients; Retrospective Studies; Rheumatoid arthritis; Rheumatology; Sensitivity and Specificity; Serology; Systemic Lupus Erythematosus; Young Adult; Germany; Systemic Lupus Erythematosus; Autoantibodies; Autoimmune Diseases; Sensitivity and Specificity

ObjectiveThis study aims to evaluate the diagnostic performance of the digital liquid chip method (DLCM) compared with indirect immunofluorescence (IIF) and chemiluminescent immunoassay (CLIA) for anti-double-stranded DNA (dsDNA) antibody detection in SLE.MethodsThe retrospective study consecutively...