Autoimmune disease and interconnections with vitamin D

• Published in: Endocrine Connections Vol. 11; no. 3; pp. 1 - 16
• Main Authors: Fletcher, Jane, Bishop, Emma L, Harrison, Stephanie R, Swift, Amelia, Cooper, Sheldon C, Dimeloe, Sarah K, Raza, Karim, Hewison, Martin
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 01.03.2022; Bioscientifica
• Subjects: autoimmune; dendritic cell; inflammation; Review; t cell; vitamin d; autoimmune; inflammation; T cell; vitamin D; dendritic cell

Vitamin D has well documented effects on calcium homeostasis and bone metabolism but recent studies suggest a much broader role for this secosteroid in human health. Key components of the vitamin D system, notably the vitamin D receptor (VDR) and the vitamin D activating enzyme (1α-hydroxylase), are...