Exogenous insulin antibody syndrome (EIAS): a clinical syndrome associated with insulin antibodies induced by exogenous insulin in diabetic patients

Insulin has been used for diabetes therapy and has achieved significant therapeutic effect. In recent years, the use of purified and recombinant human insulin preparations has markedly reduced, but not completely suppressed, the incidence of insulin antibodies (IAs). IAs induced by exogenous insulin...

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Published inEndocrine Connections Vol. 7; no. 1; pp. R47 - R55
Main Authors Hu, Xiaolei, Chen, Fengling
Format Journal Article
LanguageEnglish
Published England Bioscientifica Ltd 01.01.2018
Bioscientifica
Subjects
diabetes
exogenous insulin antibody syndrome
hyperglycaemia
hypoglycaemia
insulin antibodies
Review
hyperglycaemia
insulin antibodies
hypoglycaemia
diabetes
exogenous insulin antibody syndrome
Online AccessGet full text
ISSN2049-3614
2049-3614
DOI10.1530/EC-17-0309

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Abstract Insulin has been used for diabetes therapy and has achieved significant therapeutic effect. In recent years, the use of purified and recombinant human insulin preparations has markedly reduced, but not completely suppressed, the incidence of insulin antibodies (IAs). IAs induced by exogenous insulin in diabetic patients is associated with clinical events, which is named exogenous insulin antibody syndrome (EIAS). The present review is based on our research and summarizes the characterization of IAs, the factors affecting IA development, the clinical significance of IAs and the treatments for EIAS.
AbstractList Insulin has been used for diabetes therapy and has achieved significant therapeutic effect. In recent years, the use of purified and recombinant human insulin preparations has markedly reduced, but not completely suppressed, the incidence of insulin antibodies (IAs). IAs induced by exogenous insulin in diabetic patients is associated with clinical events, which is named exogenous insulin antibody syndrome (EIAS). The present review is based on our research and summarizes the characterization of IAs, the factors affecting IA development, the clinical significance of IAs and the treatments for EIAS.
Insulin has been used for diabetes therapy and has achieved significant therapeutic effect. In recent years, the use of purified and recombinant human insulin preparations has markedly reduced, but not completely suppressed, the incidence of insulin antibodies (IAs). IAs induced by exogenous insulin in diabetic patients is associated with clinical events, which is named exogenous insulin antibody syndrome (EIAS). The present review is based on our research and summarizes the characterization of IAs, the factors affecting IA development, the clinical significance of IAs and the treatments for EIAS.Insulin has been used for diabetes therapy and has achieved significant therapeutic effect. In recent years, the use of purified and recombinant human insulin preparations has markedly reduced, but not completely suppressed, the incidence of insulin antibodies (IAs). IAs induced by exogenous insulin in diabetic patients is associated with clinical events, which is named exogenous insulin antibody syndrome (EIAS). The present review is based on our research and summarizes the characterization of IAs, the factors affecting IA development, the clinical significance of IAs and the treatments for EIAS.
Author Chen, Fengling
Hu, Xiaolei
AuthorAffiliation Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China
Department of Endocrinology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
AuthorAffiliation_xml – name: Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China
– name: Department of Endocrinology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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  givenname: Xiaolei
  surname: Hu
  fullname: Hu, Xiaolei
  organization: Department of Endocrinology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
– sequence: 2
  givenname: Fengling
  surname: Chen
  fullname: Chen, Fengling
  email: cfl1993@126.com
  organization: Department of Endocrinology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29233817$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords hyperglycaemia
insulin antibodies
hypoglycaemia
diabetes
exogenous insulin antibody syndrome
Language English
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Snippet Insulin has been used for diabetes therapy and has achieved significant therapeutic effect. In recent years, the use of purified and recombinant human insulin...
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SubjectTerms diabetes
exogenous insulin antibody syndrome
hyperglycaemia
hypoglycaemia
insulin antibodies
Review
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Title Exogenous insulin antibody syndrome (EIAS): a clinical syndrome associated with insulin antibodies induced by exogenous insulin in diabetic patients
URI http://dx.doi.org/10.1530/EC-17-0309
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