Potentiation of the bronchoprotective effects of vasoactive intestinal peptide, isoprenaline, and theophylline against histamine challenge in anaesthetised guinea pigs by adrenomedullin

• Published in: Thorax Vol. 51; no. 12; pp. 1199 - 1202
• Main Authors: Kanazawa, H., Kawaguchi, T., Fujii, T., Shoji, S., Hirata, K., Kudoh, S., Kurihara, N., Yoshikawa, J.
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Thoracic Society 01.12.1996; BMJ Publishing Group LTD
• Subjects: Adrenomedullin; Airway Resistance - drug effects; Animals; Antihypertensive Agents - pharmacology; Antihypertensive Agents - therapeutic use; Bronchial Provocation Tests; Bronchoconstriction - drug effects; Bronchoconstriction - physiology; Bronchodilator Agents - pharmacology; Bronchodilator Agents - therapeutic use; Dose-Response Relationship, Drug; Drug Therapy, Combination; Guinea Pigs; Heart Rate - drug effects; Histamine - adverse effects; Isoproterenol - pharmacology; Isoproterenol - therapeutic use; Male; Peptides - pharmacology; Peptides - therapeutic use; Theophylline - pharmacology; Theophylline - therapeutic use; Vasoactive Intestinal Peptide - pharmacology; Vasoactive Intestinal Peptide - therapeutic use

BACKGROUND: Adrenomedullin is a hypotensive peptide recently discovered in human phaeochromocytoma which has been found to inhibit bronchoconstriction induced by histamine and acetylcholine. This study was designed to determine the manner in which adrenomedullin and other bronchodilators interact in...