Peroxisome proliferator-activated receptors, fatty acid oxidation, steatohepatitis and hepatocarcinogenesis

• Published in: Current molecular medicine Vol. 3; no. 6; p. 561
• Main Authors: Yu, Songtao, Rao, Sambasiva, Reddy, Janardan K
• Format: Journal Article
• Language: English
• Published: Netherlands 01.09.2003
• Subjects: Animals; Dietary Fats - adverse effects; Energy Metabolism; Fatty Acids - metabolism; Fatty Liver - physiopathology; Humans; Liver Neoplasms - physiopathology; Microsomes, Liver - metabolism; Mitochondria, Liver - metabolism; Oxidation-Reduction; Receptors, Cytoplasmic and Nuclear - physiology; Transcription Factors - physiology

Fatty acids are metabolized in the liver by beta-oxidation in mitochondria and peroxisomes and by omega-oxidation in microsomes. Peroxisomal beta-oxidation is responsible for the metabolism of very long chain fatty acids and mitochondrial beta-oxidation is responsible for the oxidation of short, med...