Approaches towards expression profiling the response to treatment

Over the past 8 years there has been a wealth of breast cancer gene expression studies. The majority of these studies have focused upon characterising a tumour at presentation, before treatment, rather than looking at the effects of treatment on the tumour. More recently, a number of groups have mov...

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Bibliographic Details
Published inBreast cancer research : BCR Vol. 10; no. 6; p. 115
Main Authors Sims, Andrew H, Bartlett, John M S
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 01.01.2008
National Library of Medicine - MEDLINE Abstracts
BioMed Central
Subjects
Breast Neoplasms - drug therapy
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cancer
Female
Gene expression
Gene Expression Profiling
Genes
Genetic aspects
Genetic research
Humans
Oncology, Experimental
Prognosis
Treatment Outcome
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Summary:Over the past 8 years there has been a wealth of breast cancer gene expression studies. The majority of these studies have focused upon characterising a tumour at presentation, before treatment, rather than looking at the effects of treatment on the tumour. More recently, a number of groups have moved from predicting prognosis based upon long-term follow-up to alternative approaches of using expression profiling to measure the effect of treatment on breast tumours and potentially predict response to therapy using either post-treatment samples or both pre-treatment and post-treatment samples. Whilst this provides great potential to further our understanding of the mode of action of treatments and to more accurately select which patients will benefit from a particular treatment, serious issues of experimental design must be considered.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:1465-542X
1465-5411
1465-542X
DOI:10.1186/bcr2196