LMNB1/CDKN1A Signaling Regulates the Cell Cycle and Promotes Hepatocellular Carcinoma Progression

• Published in: Current cancer drug targets Vol. 25; no. 6; p. 620
• Main Authors: Gao, Dute, Guo, Huahu, Liu, Zhaochen, Bao, Liang, Li, Suxin, Wang, Yunchao, Qiu, Jiange, Jiang, Binghua, Dang, Xiaowei
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2025
• Subjects: Animals; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21 - genetics; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Lamin Type B - genetics; Lamin Type B - metabolism; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; Mice; Mice, Nude; Middle Aged; Prognosis; Signal Transduction; CDKN1A; immune infiltration; proliferation; cell cycle; hepatocellular carcinoma; LMNB1

Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies in the world. Lamin B1 (LMNB1) is a key component of the nuclear skeleton structure. Recent studies have found that LMNB1 is overexpressed in tumor tissues and is associated with the prognosis of patients. However, the underly...