Vitamin B12 binding protein as a tumour marker for hepatocellular carcinoma

• Published in: Gut Vol. 19; no. 12; pp. 1105 - 1109
• Main Authors: Kane, S P, Murray-Lyon, I M, Paradinas, F J, Johnson, P J, Williams, R, Orr, A H, Kohn, J
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.12.1978; BMJ Publishing Group LTD
• Subjects: Adolescent; Adult; alpha-Fetoproteins - analysis; Blood Proteins - analysis; Carcinoma, Hepatocellular - blood; Female; Humans; Liver Neoplasms - blood; Male; Transcobalamins - analysis; Vitamin B 12 - blood

Grossly raised levels of tumour related vitamin B12 binding protein, reflected by rises in serum vitamin B12 and unsaturated vitamin B12 binding capacity (UBBC), were found in three of 44 patients with hepatocellular carcinoma. All three were HBsAg negative and had normal serum alpha fetoprotein lev...