Vitamin B12 binding protein as a tumour marker for hepatocellular carcinoma
Grossly raised levels of tumour related vitamin B12 binding protein, reflected by rises in serum vitamin B12 and unsaturated vitamin B12 binding capacity (UBBC), were found in three of 44 patients with hepatocellular carcinoma. All three were HBsAg negative and had normal serum alpha fetoprotein lev...
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Published in | Gut Vol. 19; no. 12; pp. 1105 - 1109 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
BMJ Publishing Group Ltd and British Society of Gastroenterology
01.12.1978
BMJ Publishing Group LTD |
Subjects | |
Online Access | Get full text |
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Summary: | Grossly raised levels of tumour related vitamin B12 binding protein, reflected by rises in serum vitamin B12 and unsaturated vitamin B12 binding capacity (UBBC), were found in three of 44 patients with hepatocellular carcinoma. All three were HBsAg negative and had normal serum alpha fetoprotein levels. The patients did not have underlying cirrhosis and the tumours contained characteristic intracellular inclusions. In the first patient the UBBC level fell during a partial remission induced by adriamycin therapy and in the second patient UBBC levels rose with progression of her disease. In the third patient serum B12 binding protein levels fell after tumour resection. Assay and subsequent monitoring of serum vitamin B12 and UBCC may prove valuable in the assessment and follow-up of some patients with hepatocellular carcinoma whose alpha fetoprotein levels are normal. |
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Bibliography: | istex:45AF028280466279AC7D6F2FCA925D62BBE084A1 href:gutjnl-19-1105.pdf PMID:84776 ark:/67375/NVC-ZLXQVP5L-N local:gutjnl;19/12/1105 ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 |
ISSN: | 0017-5749 1468-3288 1458-3288 |
DOI: | 10.1136/gut.19.12.1105 |