Secondary mitral regurgitation: pathophysiology, proportionality and prognosis

• Published in: Heart (British Cardiac Society) Vol. 106; no. 10; pp. 716 - 723
• Main Authors: Chehab, Omar, Roberts-Thomson, Ross, Ng Yin Ling, Clarissa, Marber, Michael, Prendergast, Bernard D, Rajani, Ronak, Redwood, Simon R
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Cardiovascular Society 01.05.2020; BMJ Publishing Group LTD
• Subjects: Cardiology; Cardiomyopathies - complications; Cardiomyopathies - physiopathology; Cardiomyopathy; Ejection fraction; functional mitral regurgitation; Heart failure; Heart Failure - physiopathology; Heart Failure - therapy; Humans; Integrated approach; mitral regurgitation; Mitral Valve Annuloplasty - methods; Mitral Valve Annuloplasty - trends; Mitral Valve Insufficiency - diagnosis; Mitral Valve Insufficiency - etiology; Mitral Valve Insufficiency - physiopathology; Mitral Valve Insufficiency - surgery; Mortality; Patients; Prognosis; Pulmonary arteries; Review; secondary mitral regurgitation; systolic left ventricular dysfunction; Treatment Outcome; Veins & arteries; Ventricular Remodeling; heart failure; mitral regurgitation; secondary mitral regurgitation; functional mitral regurgitation; systolic left ventricular dysfunction

Secondary mitral regurgitation (SMR) occurs as a result of multifactorial left atrioventricular dysfunction and maleficent remodelling. It is the most common and undertreated form of mitral regurgitation (MR) and is associated with a very poor prognosis. Whether SMR is a bystander reflecting the sev...