Role of germline aberrations affecting CTNNA1, MAP3K6 and MYD88 in gastric cancer susceptibility

• Published in: Journal of medical genetics Vol. 55; no. 10; pp. 669 - 674
• Main Authors: Weren, Robbert D A, van der Post, Rachel S, Vogelaar, Ingrid P, van Krieken, J Han, Spruijt, Liesbeth, Lubinski, Jan, Jakubowska, Anna, Teodorczyk, Urszula, Aalfs, Cora M, van Hest, Liselotte P, Oliveira, Carla, Kamping, Eveline J, Schackert, Hans K, Ranzani, Guglielmina N, Gómez García, Encarna B, Hes, Frederik J, Holinski-Feder, Elke, Genuardi, Maurizio, Ausems, Margreet G E M, Sijmons, Rolf H, Wagner, Anja, van der Kolk, Lizet E, Cats, Annemieke, Bjørnevoll, Inga, Hoogerbrugge, Nicoline, Ligtenberg, Marjolijn J L
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.10.2018; BMJ Publishing Group
• Series: Short report
• Subjects: Adult; Aged; alpha Catenin - genetics; Antigens, CD - genetics; Bioinformatics; Cadherins - genetics; Cancer Genetics; Cohort Studies; Consortia; Defects; Deoxyribonucleic acid; DNA; E-cadherin; Europe; Family medical history; Female; Gastric cancer; Genes; Genetic Predisposition to Disease; Genetic testing; Germ-Line Mutation; High-Throughput Nucleotide Sequencing; Humans; Male; MAP Kinase Kinase Kinases - genetics; Middle Aged; Mutation; MyD88 protein; Myeloid Differentiation Factor 88 - genetics; Patients; Proteins; Sequence Analysis, DNA; Stomach Neoplasms - genetics; Young Adult; Europe; Netherlands; cancer: gastric; ctnna1 – map3k6 – myd88; next generation sequencing; heritability

BackgroundIn approximately 10% of all gastric cancer (GC) cases, a heritable cause is suspected. A subset of these cases have a causative germline CDH1 mutation; however, in most cases the cause remains unknown. Our objective was to assess to what extent these remaining cases may be explained by ger...