Digitoxin and its analogs as novel cancer therapeutics

A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinical profile. New scientific avenues have shown that manipulating the chemical structure of th...

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Published inExperimental hematology & oncology Vol. 1; no. 1; p. 4
Main Authors Elbaz, Hosam A, Stueckle, Todd A, Tse, William, Rojanasakul, Yon, Dinu, Cerasela Zoica
Format Journal Article
LanguageEnglish
Published London BioMed Central 05.04.2012
BioMed Central Ltd
BMC
Subjects
Cancer Research
Hematology
Medicine
Medicine & Public Health
Oncology
Review
Anticancer Mechanism
Cell Cycle Regulatory Protein
Digitoxin
Mitotic Catastrophe
Intracellular Sodium
Online AccessGet full text
ISSN2162-3619
2162-3619
DOI10.1186/2162-3619-1-4

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Abstract A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinical profile. New scientific avenues have shown that manipulating the chemical structure of the saccharide moiety of digitoxin leads to synthetic analogs with increased cytotoxic activity. However, the anticancer mechanism of digitoxin or synthetic analogs is still subject to study while concerns about digitoxin's cardiotoxicity preclude its clinical application in cancer therapeutics. This review focuses on digitoxin and its analogs, and their cytotoxicity against cancer cells. Moreover, a new perspective on the pharmacological aspects of digitoxin and its analogs is provided to emphasize new research directions for developing potent chemotherapeutic drugs.
AbstractList A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinical profile. New scientific avenues have shown that manipulating the chemical structure of the saccharide moiety of digitoxin leads to synthetic analogs with increased cytotoxic activity. However, the anticancer mechanism of digitoxin or synthetic analogs is still subject to study while concerns about digitoxin's cardiotoxicity preclude its clinical application in cancer therapeutics. This review focuses on digitoxin and its analogs, and their cytotoxicity against cancer cells. Moreover, a new perspective on the pharmacological aspects of digitoxin and its analogs is provided to emphasize new research directions for developing potent chemotherapeutic drugs.
Abstract A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinical profile. New scientific avenues have shown that manipulating the chemical structure of the saccharide moiety of digitoxin leads to synthetic analogs with increased cytotoxic activity. However, the anticancer mechanism of digitoxin or synthetic analogs is still subject to study while concerns about digitoxin's cardiotoxicity preclude its clinical application in cancer therapeutics. This review focuses on digitoxin and its analogs, and their cytotoxicity against cancer cells. Moreover, a new perspective on the pharmacological aspects of digitoxin and its analogs is provided to emphasize new research directions for developing potent chemotherapeutic drugs.
A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinical profile. New scientific avenues have shown that manipulating the chemical structure of the saccharide moiety of digitoxin leads to synthetic analogs with increased cytotoxic activity. However, the anticancer mechanism of digitoxin or synthetic analogs is still subject to study while concerns about digitoxin's cardiotoxicity preclude its clinical application in cancer therapeutics. This review focuses on digitoxin and its analogs, and their cytotoxicity against cancer cells. Moreover, a new perspective on the pharmacological aspects of digitoxin and its analogs is provided to emphasize new research directions for developing potent chemotherapeutic drugs. A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a prolonged half-life and a well-established clinical profile. New scientific avenues have shown that manipulating the chemical structure of the saccharide moiety of digitoxin leads to synthetic analogs with increased cytotoxic activity. However, the anticancer mechanism of digitoxin or synthetic analogs is still subject to study while concerns about digitoxin's cardiotoxicity preclude its clinical application in cancer therapeutics. This review focuses on digitoxin and its analogs, and their cytotoxicity against cancer cells. Moreover, a new perspective on the pharmacological aspects of digitoxin and its analogs is provided to emphasize new research directions for developing potent chemotherapeutic drugs.
ArticleNumber 4
Author Tse, William
Stueckle, Todd A
Rojanasakul, Yon
Elbaz, Hosam A
Dinu, Cerasela Zoica
AuthorAffiliation 1 Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA
6 Department of Chemical Engineering, West Virginia University, College of Engineering and Mineral Resources, PO Box 6102, ESB 445, Morgantown, WV 26506, USA
5 Department of Basic Pharmaceutical Sciences, West Virginia University, PO Box 9530, 1 Medical Center Drive, Morgantown, WV 26506, USA
3 Department of Chemical Engineering, West Virginia University, Morgantown, WV, USA
4 National Institute for Occupational Safety and Health, Morgantown, WV, USA
2 Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV, USA
AuthorAffiliation_xml – name: 4 National Institute for Occupational Safety and Health, Morgantown, WV, USA
– name: 5 Department of Basic Pharmaceutical Sciences, West Virginia University, PO Box 9530, 1 Medical Center Drive, Morgantown, WV 26506, USA
– name: 6 Department of Chemical Engineering, West Virginia University, College of Engineering and Mineral Resources, PO Box 6102, ESB 445, Morgantown, WV 26506, USA
– name: 1 Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA
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  organization: Department of Basic Pharmaceutical Sciences, West Virginia University, National Institute for Occupational Safety and Health
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  givenname: William
  surname: Tse
  fullname: Tse, William
  organization: Mary Babb Randolph Cancer Center, West Virginia University
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  givenname: Yon
  surname: Rojanasakul
  fullname: Rojanasakul, Yon
  email: yrojan@hsc.wvu.edu
  organization: Department of Basic Pharmaceutical Sciences, West Virginia University, Department of Basic Pharmaceutical Sciences, West Virginia University
– sequence: 5
  givenname: Cerasela Zoica
  surname: Dinu
  fullname: Dinu, Cerasela Zoica
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Copyright Elbaz et al; licensee BioMed Central Ltd. 2012 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright ©2012 Elbaz et al; licensee BioMed Central Ltd. 2012 Elbaz et al; licensee BioMed Central Ltd.
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– notice: Copyright ©2012 Elbaz et al; licensee BioMed Central Ltd. 2012 Elbaz et al; licensee BioMed Central Ltd.
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Issue 1
Keywords Anticancer Mechanism
Cell Cycle Regulatory Protein
Digitoxin
Mitotic Catastrophe
Intracellular Sodium
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Snippet A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. Digitoxin has a...
Abstract A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations....
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SubjectTerms Cancer Research
Hematology
Medicine
Medicine & Public Health
Oncology
Review
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Title Digitoxin and its analogs as novel cancer therapeutics
URI https://link.springer.com/article/10.1186/2162-3619-1-4
https://www.ncbi.nlm.nih.gov/pubmed/23210930
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