Design, Synthesis, Pharmacological Evaluation and Vascular Effects of Delphinidin Analogues

• Published in: Current pharmaceutical design Vol. 24; no. 46; p. 5580
• Main Authors: Legeay, Samuel, Trân, Kien, Abatuci, Yannick, Justiniano, Hélène, Lugnier, Claire, Duval, Olivier, Helesbeux, Jean-Jacques, Faure, Sébastien
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2018
• Subjects: Animals; Anthocyanins - chemical synthesis; Anthocyanins - pharmacology; Aorta, Thoracic - drug effects; Drug Design; Estrogen Receptor alpha; Human Umbilical Vein Endothelial Cells; Humans; Mice; Molecular Structure; Nitric Oxide; Vasodilator Agents - chemical synthesis; Vasodilator Agents - pharmacology; Anthocyanidin; estrogen receptor α pathway; structure-activity relationships; vasorelaxation; phosphodiesterase inhibition; nitrite oxide

Among polyphenolic compounds suggested to prevent cardiovascular diseases (CVDs) and to explain the "French paradox", the anthocyanidin delphinidin (Dp) has been reported to support at least partly the vascular beneficial effects of dietary polyphenolic compounds including those from fruit...