Acceleration of regeneration of mucosa in small intestine damaged by ionizing radiation using anabolic steroids

• Published in: Radiation research Vol. 175; no. 3; p. 367
• Main Authors: Ishihara, Hiroshi, Tanaka, Izumi, Yakumaru, Haruko, Tanaka, Mika, Satoh, Akiko, Ishiwata, Akiko, Yokochi, Kazuko, Kurematsu, Ayako, Ueda, Jun-ichi, Shibata, Tomohiro, Hachiya, Misao, Akashi, Makoto
• Format: Journal Article
• Language: English
• Published: United States 01.03.2011
• Subjects: Anabolic Agents - pharmacology; Animals; Cell Line; Cell Proliferation - drug effects; Cell Proliferation - radiation effects; Dose-Response Relationship, Drug; Epithelial Cells - drug effects; Epithelial Cells - radiation effects; Intestinal Mucosa - cytology; Intestinal Mucosa - drug effects; Intestinal Mucosa - physiology; Intestinal Mucosa - radiation effects; Intestine, Small - cytology; Intestine, Small - diagnostic imaging; Intestine, Small - drug effects; Intestine, Small - physiology; Male; Mice; Radiography; Rats; Regeneration - drug effects; Regeneration - radiation effects; Steroids - pharmacology; Survival Rate; Time Factors

Damage to intestine is a serious problem after accidental radiation exposure. To examine substances to ameliorate damage by postirradiation administration, we focused on the regeneration process after irradiation of the intestine. Using experimental systems, the effects of clinically used sex hormon...