Mechanism of Action and Related Natural Regulators of Nrf2 in Nonalcoholic Fatty Liver Disease

• Published in: Current drug delivery Vol. 21; no. 10; p. 1300
• Main Authors: Yu, Wenfei, Zhang, Fengxia, Meng, Decheng, Zhang, Xin, Feng, Yanan, Yin, Guoliang, Liang, Pengpeng, Chen, Suwen, Liu, Hongshuai
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2024
• Subjects: Animals; Antioxidants - pharmacology; Antioxidants - therapeutic use; Biological Products - pharmacology; Biological Products - therapeutic use; Humans; NF-E2-Related Factor 2 - metabolism; Non-alcoholic Fatty Liver Disease - drug therapy; Non-alcoholic Fatty Liver Disease - metabolism; Oxidative Stress - drug effects; Signal Transduction - drug effects; FFA; NAFLD; TG; Nrf2; inflammation; natural regulators
• ISSN: 1875-5704
• DOI: 10.2174/0115672018260113231023064614

With the acceleration of people's pace of life, non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in the world, which greatly threatens people's health and safety. Therefore, there is still an urgent need for higher-quality research and treatment in this area. Nuclear factor Red-2-related factor 2 (Nrf2), as a key transcription factor in the regulation of oxidative stress, plays an important role in inducing the body's antioxidant response. Although there are no approved drugs targeting Nrf2 to treat NAFLD so far, it is still of great significance to target Nrf2 to alleviate NAFLD. In recent years, studies have reported that many natural products treat NAFLD by acting on Nrf2 or Nrf2 pathways. This article reviews the role of Nrf2 in the pathogenesis of NAFLD and summarizes the currently reported natural products targeting Nrf2 or Nrf2 pathway for the treatment of NAFLD, which provides new ideas for the development of new NAFLD-related drugs.