Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study

• Published in: Gut Vol. 70; no. 1; pp. 85 - 91
• Main Authors: Zhang, Bing, Wang, Hohui E, Bai, Ya-Mei, Tsai, Shih-Jen, Su, Tung-Ping, Chen, Tzeng-Ji, Wang, Yen-Po, Chen, Mu-Hong
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.01.2021; BMJ Publishing Group LTD
• Subjects: Age Factors; Aged; Aged, 80 and over; Brain research; Case-Control Studies; Central nervous system; Clinical medicine; Codes; Comparative analysis; Crohn's disease; Databases, Factual; Dementia; Dementia - diagnosis; Dementia - epidemiology; Dementia disorders; Diagnosis; Disease; enteric bacterial microflora; Enteric nervous system; Female; Gastroenterology; Gut-brain axis; Health insurance; Humans; IBD; Incidence; Inflammation; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - complications; Inflammatory Bowel Diseases - diagnosis; Inflammatory Bowel Diseases - psychology; Intestine; Longitudinal Studies; Male; Mental depression; Middle Aged; Movement disorders; Nervous system; neurobiology; Neurodegenerative diseases; Ostomy; Parkinson's disease; Patients; Population studies; Quality of life; Risk Factors; Sex; Sex differences; Taiwan - epidemiology; Ulcerative colitis; Taiwan; United States > US; neurobiology; IBD; inflammation; enteric bacterial microflora

ObjectiveIncreasing evidence supports reciprocal communication between the enteric and the central nervous system in disease, termed the ‘gut–brain axis’. Recent findings suggest a connection between IBD and development of Parkinson’s disease. The role of IBD in dementia, another insidious neurodege...