Exploration of the Potential Mechanism of Yujin Powder Treating Dampness-heat Diarrhea by Integrating UPLC-MS/MS and Network Pharmacology Prediction

• Published in: Combinatorial chemistry & high throughput screening Vol. 27; no. 10; p. 1466
• Main Authors: Jiang, Li-Dong, Zhang, Wang-Dong, Wang, Bao-Shan, Cai, Yan-Zi, Qin, Xue, Zhao, Wen-Bo, Ji, Peng, Yuan, Zi-Wen, Wei, Yan-Ming, Yao, Wan-Ling
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2024
• Subjects: Chromatography, High Pressure Liquid; Diarrhea - drug therapy; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - pharmacology; Humans; Liquid Chromatography-Mass Spectrometry; Medicine, Chinese Traditional; Molecular Docking Simulation; Network Pharmacology; Powders - chemistry; Protein Interaction Maps - drug effects; Tandem Mass Spectrometry; PPI; UPLC-MS/MS; dampness-heat diarrhea; molecular docking; Yujin powder; network pharmacology

Yujin powder (YJP) is a classic prescription for treating dampness-heat diarrhea (DHD) in Traditional Chinese Medicine (TCM), but the main functional active ingredients and the exact mechanisms have not been systematically studied. This study aimed to preliminarily explore the potential mechanisms o...