Computational Drug Repositioning by Target Hopping: A Use Case in Chagas Disease

Drug repositioning aims to identify novel indications for existing drugs. One approach to repositioning exploits shared binding sites between the drug targets and other proteins. Here, we review the principle and algorithms of such target hopping and illustrate them in Chagas disease, an in Latin Am...

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Bibliographic Details
Published inCurrent pharmaceutical design Vol. 22; no. 21; p. 3124
Main Authors Haupt, V Joachim, Aguilar Uvalle, Jesús E, Salentin, Sebastian, Daminelli, Simone, Leonhardt, Franziska, Konc, Janez, Schroeder, Michael
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.06.2016
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Summary:Drug repositioning aims to identify novel indications for existing drugs. One approach to repositioning exploits shared binding sites between the drug targets and other proteins. Here, we review the principle and algorithms of such target hopping and illustrate them in Chagas disease, an in Latin America widely spread, but neglected disease. We demonstrate how target hopping recovers known treatments for Chagas disease and predicts novel drugs, such as the antiviral foscarnet, which we predict to target Farnesyl Pyrophosphate Synthase in Trypanosoma cruzi, the causative agent of Chagas disease.
ISSN:1873-4286
DOI:10.2174/1381612822666160224143008