Targeted Delivery of Diphtheria Toxin into VEGFR1/VEGFR2 Overexpressing Cells Induces Anti-angiogenesis Activity

• Published in: Current protein & peptide science Vol. 25; no. 7; p. 567
• Main Authors: Kazemi-Lomedasht, Fatemeh, Taghizadeh-Hesary, Farzad, Faal, Zahra, Behdani, Mahdi
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2024
• Subjects: Angiogenesis Inhibitors - chemistry; Angiogenesis Inhibitors - genetics; Angiogenesis Inhibitors - pharmacology; Cell Movement - drug effects; Cell Survival - drug effects; Diphtheria Toxin - genetics; Diphtheria Toxin - metabolism; Diphtheria Toxin - pharmacology; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Gene Expression; Human Umbilical Vein Endothelial Cells - metabolism; Humans; Neovascularization, Pathologic - drug therapy; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - metabolism; Neovascularization, Pathologic - pathology; Recombinant Fusion Proteins - genetics; Recombinant Fusion Proteins - metabolism; Recombinant Fusion Proteins - pharmacology; Vascular Endothelial Growth Factor Receptor-1 - genetics; Vascular Endothelial Growth Factor Receptor-1 - metabolism; Vascular Endothelial Growth Factor Receptor-2 - genetics; Vascular Endothelial Growth Factor Receptor-2 - metabolism; VEGFR2; diphtheria toxin; VGB3; targeted toxin; VEGFR1; angiogenesis

Vascular Endothelial Growth Factor Receptors (VEGFR1 and VEGFR2) are tyrosine kinase receptors expressed on endothelial cells and tumor vessels and play an important role in angiogenesis. In this study, three repeats of VEGFR1 and VEGFR2 binding peptide (VGB3) were genetically fused to the truncated...