Causal Effects of Blood Metabolites and Obstructive Sleep Apnea: A Mendelian Randomization Study

• Published in: Current neurovascular research Vol. 21; no. 1; p. 101
• Main Authors: Wu, Jing-Hao, Yang, Ying-Hao, Wang, Yun-Chao, Yu, Wen-Kai, Li, Shan-Shan, Mei, Yun-Yun, Ce-Zong, Zhou, Zi-Han, Zhu, Hang-Hang, He, Liu-Chang, Li, Xin-Yu, Shi, Chang-He, Li, Yu-Sheng
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2024
• Subjects: Biomarkers - blood; Female; Humans; Male; Mendelian Randomization Analysis; Risk Factors; Sleep Apnea, Obstructive - blood; Sleep Apnea, Obstructive - genetics; obstructive sleep apnea; multivariable mendelian randomization; Metabolites; pleiotropy; MR bayesian model averaging; mendelian randomization

Obstructive sleep apnea (OSA) is one of the most common forms of sleep-disordered breathing. Studies have shown that certain changes in metabolism play an important role in the pathophysiology of OSA. However, the causal relationship between these metabolites and OSA remains unclear. We use a mendel...