Survivin Modulators: An Updated Patent Review (2011-2015)

• Published in: Recent patents on anti-cancer drug discovery Vol. 11; no. 2; p. 152
• Main Authors: Roy, Kislay, Singh, Neha, Kanwar, Rupinder K, Kanwar, Jagat R
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.04.2016
• Subjects: Amino Acid Sequence; Animals; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Humans; Inhibitor of Apoptosis Proteins - antagonists & inhibitors; Inhibitor of Apoptosis Proteins - genetics; Inhibitor of Apoptosis Proteins - metabolism; Inhibitor of Apoptosis Proteins - physiology; Neoplasms - drug therapy; Neoplasms - metabolism; Patents as Topic; Protein Structure, Secondary; Taxoids - pharmacology; Taxoids - therapeutic use

Survivin is widely overexpressed in many forms of cancer and studies have related high survivin expression with poor survival rates. Although, there have been several attempts to target survivin, most therapeutics haven't shown substantial success in clinical trials therefore, authors wish to a...