Mosaic chromosomal aberrations in synovial fibroblasts of patients with rheumatoid arthritis, osteoarthritis, and other inflammatory joint diseases

• Published in: Arthritis research Vol. 3; no. 5; pp. 319 - 330
• Main Authors: Kinne, R W, Liehr, T, Beensen, V, Kunisch, E, Zimmermann, T, Holland, H, Pfeiffer, R, Stahl, H D, Lungershausen, W, Hein, G, Roth, A, Emmrich, F, Claussen, U, Froster, U G
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.01.2001; BioMed Central
• Subjects: Analysis; Arthritis, Psoriatic - blood; Arthritis, Psoriatic - genetics; Arthritis, Psoriatic - pathology; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - genetics; Arthritis, Rheumatoid - pathology; Care and treatment; Cell Nucleus - genetics; Cell Nucleus - pathology; Chromosome Aberrations; Chromosome abnormalities; Chromosome Banding; Diagnosis; Fibroblasts; Fibroblasts - pathology; Humans; In Situ Hybridization, Fluorescence; Interphase; Mosaicism; Osteoarthritis; Osteoarthritis - blood; Osteoarthritis - genetics; Osteoarthritis - pathology; Rheumatoid arthritis; Spondylitis, Ankylosing - blood; Spondylitis, Ankylosing - genetics; Spondylitis, Ankylosing - pathology; Synovial Membrane - pathology; Trisomy; Germany

Chromosomal aberrations were comparatively assessed in nuclei extracted from synovial tissue, primary-culture (P-0) synovial cells, and early-passage synovial fibroblasts (SFB; 98% enrichment; P-1, P-4 [passage 1, passage 4]) from patients with rheumatoid arthritis (RA; n = 21), osteoarthritis (OA;...