MicroRNAs as regulators, biomarkers and therapeutic targets in liver diseases

• Published in: Gut Vol. 70; no. 4; pp. 784 - 795
• Main Authors: Wang, Xiaolin, He, Yong, Mackowiak, Bryan, Gao, Bin
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.04.2021; BMJ Publishing Group LTD
• Subjects: Alcoholism; Apoptosis; Biomarkers; cancer; Cell adhesion & migration; Cell interactions; Cell signaling; Chemokines; Collagen; Cytokines; Diagnosis; Extracellular vesicles; Fatty liver; Fibrosis; Gene expression; Growth factors; Hepatitis; Hepatocellular carcinoma; Hepatocytes; Kinases; Leukocytes (neutrophilic); Ligands; Liver cancer; Liver diseases; MicroRNAs; miRNA; Non-coding RNA; Phosphatase; Post-transcription; Proteins; Recent advances in basic science; RNA polymerase; Roles; Stellate cells; Therapeutic applications; Tumors; cancer; fatty liver; fibrosis; hepatitis

MicroRNAs (miRNAs) are small, non-coding RNAs that post-transcriptionally regulate gene expression by binding to specific mRNA targets and promoting their degradation and/or translational inhibition. miRNAs regulate both physiological and pathological liver functions. Altered expression of miRNAs is...