Two-step versus 1-step subretinal injection to compare subretinal drug delivery: a randomised study protocol

• Published in: BMJ open Vol. 11; no. 12; p. e049976
• Main Authors: Simunovic, Matthew P, Shao, Emily H, Osaadon, Perach, Sasongko, Muhammad Bayu, Too, Lay Khoon
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 15.12.2021; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Protocol
• Subjects: Humans; Laboratories; Macular degeneration; Macular Degeneration - complications; Macular Degeneration - drug therapy; medical retina; Methods; Monoclonal antibodies; Ophthalmology; Randomized Controlled Trials as Topic; Regulatory approval; Retina; Retinal Hemorrhage - drug therapy; Retinal Hemorrhage - surgery; Surgeons; Tissue Plasminogen Activator; Tomography; vetreoretinal; Visual Acuity; Vitrectomy - methods; United States > US; vetreoretinal; medical retina; ophthalmology

IntroductionThere is increasing interest in subretinal injections as a surgical procedure, largely as a result of emerging treatments for ocular diseases which necessitate this manoeuvre. However, surgical variables in the efficacy of such treatments have to date been largely overlooked and the prop...