Recent Progress in Histone Deacetylase Inhibitors as Anticancer Agents

• Published in: Current medicinal chemistry
• Main Authors: Cappellacci, Loredana, Perinelli, Diego R, Maggi, Filippo, Grifantini, Mario, Petrelli, Riccardo
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2020
• Subjects: QSAR of HDACis; molecular modeling studies of HDACis; epigenetic; natural HDACis; HDACis as antitumor agents; Histone deacetylase inhibitors (HDACis); histone deacetylases and cancer

Histone deacetylase (HDAC) inhibitors are a relatively new class of anti-cancer agents that play important roles in epigenetic or non-epigenetic regulation, inducing death, apoptosis, and cell cycle arrest in cancer cells. Recently, their use has been clinically validated in cancer patients resultin...