Small Molecule CDK Inhibitors for the Therapeutic Management of Cancer

• Published in: Current topics in medicinal chemistry Vol. 20; no. 17; p. 1535
• Main Authors: Goel, Bharat, Tripathi, Nancy, Bhardwaj, Nivedita, Jain, Shreyans K
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2020
• Subjects: Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Cyclin-Dependent Kinases - antagonists & inhibitors; Cyclin-Dependent Kinases - metabolism; Humans; Molecular Structure; Neoplasms - drug therapy; Neoplasms - metabolism; Protein Kinase Inhibitors - chemistry; Protein Kinase Inhibitors - pharmacology; Small Molecule Libraries - chemistry; Small Molecule Libraries - pharmacology; Cyclin-dependent kinase; Clinical trial; CDK inhibitors; Natural products; Cell cycle; Cancer

Cyclin-dependent kinases (CDKs) are a group of multifunctional enzymes consisting of catalytic and regulatory subunits. The regulatory subunit, cyclin, remains dissociated under normal circumstances, and complexation of cyclin with the catalytic subunit of CDK leads to its activation for phosphoryla...