From Levinthal's Paradox to the Effects of Cell Environmental Perturbation on Protein Folding

• Published in: Current medicinal chemistry Vol. 26; no. 42; p. 7537
• Main Authors: Zeng, Juan, Huang, Zunnan
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2019
• Subjects: Acetylation; Amino Acid Sequence; Glycosylation; Phosphorylation; Protein Conformation; Protein Folding; Protein Processing, Post-Translational; Proteins - metabolism; Temperature; crowded cell-like environment; glycosylation and acetylation; Protein folding; phosphorylation; environmental temperature; free energy landscape

The rapidly increasing number of known protein sequences calls for more efficient methods to predict the Three-Dimensional (3D) structures of proteins, thus providing basic knowledge for rational drug design. Understanding the folding mechanism of proteins is valuable for predicting their 3D structu...