Leptin in septic arthritis: decreased levels during infection and amelioration of disease activity upon its administration

• Published in: Arthritis research Vol. 3; no. 6; pp. 389 - 394
• Main Authors: Hultgren, O H, Tarkowski, A
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.01.2001; BioMed Central
• Subjects: Animals; Arthritis, Infectious; Arthritis, Infectious - blood; Arthritis, Infectious - drug therapy; Arthritis, Infectious - mortality; Care and treatment; Eating - drug effects; Energy Metabolism - drug effects; Infectious arthritis; Interleukin-6 - biosynthesis; Interleukin-6 - blood; Leptin; Leptin - blood; Leptin - pharmacology; Male; Mice; Mice, Inbred C57BL; Staphylococcal Infections - complications; Staphylococcus aureus; Staphylococcus aureus infections; Testing; Weight Loss; Sweden

Weight loss is typically found during severe infections, e.g. septic arthritis. The aim of our study was to evaluate the role of leptin, regulator of food intake and energy expenditure, for the development of Staphylococcus aureus-triggered arthritis. Leptin production was found to be decreased duri...