Oxidative Stress and Decreased Mitochondrial Superoxide Dismutase 2 and Peroxiredoxins 1 and 4 Based Mechanism of Concurrent Activation of AMPK and mTOR in Alzheimer's Disease

• Published in: Current Alzheimer research Vol. 15; no. 8; p. 764
• Main Authors: Majd, Shohreh, Power, John H T
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2018
• Subjects: peroxiredoxin; Alzheimer’s disease; mitochondrial antioxidant enzymes; adenosine monophosphate kinase protein kinase; superoxide dismutase; mammalian target for rapamycin; tau phosphorylation; oxidative stress

Emerging evidence supports the hypothesis that metabolism dysfunction is involved in pathogenesis of Alzheimer's disease (AD). One aspect of metabolic dysfunction includes dysregulation of adenosine monophosphate kinase protein kinase (AMPK) and mammalian target of rapamycin (mTOR) metabolic ax...