Brain Gangliosides in Alzheimer's Disease: Increased Expression of Cholinergic Neuron-Specific Gangliosides

• Published in: Current Alzheimer research Vol. 14; no. 6; p. 586
• Main Authors: Fukami, Yuki, Ariga, Toshio, Yamada, Mitsunori, Yuki, Nobuhiro
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2017
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - pathology; Antibodies - metabolism; Antigens, Surface - immunology; Antigens, Surface - metabolism; Brain - pathology; Cholinergic Neurons - metabolism; Chromatography, High Pressure Liquid; Female; Gangliosides - immunology; Gangliosides - metabolism; Humans; Male; Middle Aged; Statistics, Nonparametric; dementia; cholinergic neuron; Chol-1α antigen; Alzheimer's disease; ganglioside

Gangliosides are enriched in the neuronal membranes. Gangliosides are shown to interact with amyloid-β proteins, leading to formation of amyloid fibrils in Alzheimer's disease (AD) brains. Several earlier studies indicated that the alterations of ganglioside metabolism could contribute the path...