Virological and Clinical Response to Interferon-Free Regimens in Patients with HCV-Related Mixed Cryoglobulinemia: Preliminary Results of a Prospective Pilot Study

• Published in: Current drug targets Vol. 18; no. 7; p. 772
• Main Authors: Gragnani, Laura, Piluso, Alessia, Urraro, Teresa, Fabbrizzi, Alessio, Fognani, Elisa, Petraccia, Luisa, Genovesi, Alessandro, Giubilei, Lidia, Ranieri, Jessica, Stasi, Cristina, Monti, Monica, Zignego, Anna Linda
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2017
• Subjects: Aged; Anilides - administration & dosage; Anilides - pharmacology; Antiviral Agents - administration & dosage; Antiviral Agents - pharmacology; Carbamates - administration & dosage; Carbamates - pharmacology; Cryoglobulinemia - drug therapy; Cryoglobulinemia - virology; Female; Hepacivirus - drug effects; Hepacivirus - genetics; Hepatitis C, Chronic - complications; Hepatitis C, Chronic - drug therapy; Humans; Macrocyclic Compounds - administration & dosage; Macrocyclic Compounds - pharmacology; Male; Middle Aged; Pilot Projects; Prospective Studies; Ritonavir - administration & dosage; Ritonavir - pharmacology; RNA, Viral - drug effects; Treatment Outcome; interferon-free (IFN-free); Antiviral treatment; safety; direct-acting antiviral (DAA); HCV; efficacy; mixed cryoglobulinemia

Mixed Cryoglobulinemia (MC) is the most frequent extrahepatic manifestation of Hepatitis C virus (HCV) infection. MC is an autoimmune /B-cell lymphoproliferative disorder characterized by circulating immune-complexes, named cryoglobulins. MC patients exhibit symptoms due to a systemic vasculitis of...