Peptide-based PROTACs: Current Challenges and Future Perspectives

• Published in: Current medicinal chemistry
• Main Authors: Wang, Huidan, Chen, Miao, Zhang, Xiaoyuan, Xie, Songbo, Qin, Jie, Li, Jingrui
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2024
• Subjects: Delivery; Peptide-based PROTAC; Undruggable protein; Targeted protein degradation

Proteolysis-targeting chimeras (PROTACs) are an attractive means to target previously undruggable or drug-resistant mutant proteins. While small molecule-based PROTACs are stable and can cross cell membranes, there is limited availability of suitable small molecule warheads capable of recruiting pro...