Nuclear translocation of plasma membrane protein ADCY7 potentiates T cell-mediated antitumour immunity in HCC

• Published in: Gut Vol. 74; no. 1; pp. 128 - 140
• Main Authors: Chen, Jianan, Jiang, Youhai, Hou, Minghui, Liu, Chunliang, Liu, Erdong, Zong, Yali, Wang, Xiang, Meng, Zhengyuan, Gu, Mingye, Su, Yu, Wang, Hongyang, Fu, Jing
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.01.2025; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Adenylate cyclase; Adenylyl Cyclases - genetics; Adenylyl Cyclases - metabolism; Animal models; Animals; Antitumor activity; Candidates; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Caveolae; CCAAT/enhancer-binding protein; CD8 antigen; Cell Line, Tumor; Cell Nucleus - metabolism; Cell therapy; Cell-mediated immunity; Chromatin; CRISPR; Endocytosis; Exosomes; Flow cytometry; Genes; Genomes; HEPATOCELLULAR CARCINOMA; Hepatology; Humans; IMMUNE RESPONSE; Immune system; Immunity (Disease); Immunological tolerance; Immunoprecipitation; Immunosuppressive agents; Immunosurveillance; Immunotherapy; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - immunology; Liver Neoplasms - pathology; Lymphocytes; Lymphocytes T; Malignancy; Medical prognosis; Metastases; Mice; Microenvironments; Original Research; Protein transport; Proteins; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Tumor Escape - genetics; Tumor Microenvironment - immunology; Tumors; HEPATOCELLULAR CARCINOMA; IMMUNE RESPONSE

BackgroundThe potency of T cell-mediated responses is a determinant of immunotherapy effectiveness in treating malignancies; however, the clinical efficacy of T-cell therapies has been limited in hepatocellular carcinoma (HCC) owing to the extensive immunosuppressive microenvironment.ObjectiveHere,...