Nuclear translocation of plasma membrane protein ADCY7 potentiates T cell-mediated antitumour immunity in HCC - Chen, Jianan; Jiang, Youhai; Hou, Minghui; Liu, Chunliang; Liu, Erdong; Zong, Yali; Wang, Xiang; Meng, Zhengyuan; Gu, Mingye; Su, Yu; Wang, Hongyang; Fu, Jing (Gut, 2025)
Keywords: Adenylate cyclase; Adenylyl Cyclases - genetics; Adenylyl Cyclases - metabolism; Animal models; Animals; Antitumor activity; Candidates; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Caveolae; CCAAT/enhancer-binding protein; CD8 antigen; Cell Line, Tumor; Cell Nucleus - metabolism; Cell therapy; Cell-mediated immunity; Chromatin; CRISPR; Endocytosis; Exosomes; Flow cytometry; Genes; Genomes; HEPATOCELLULAR CARCINOMA; Hepatology; Humans; IMMUNE RESPONSE; Immune system; Immunity (Disease); Immunological tolerance; Immunoprecipitation; Immunosuppressive agents; Immunosurveillance; Immunotherapy; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - immunology; Liver Neoplasms - pathology; Lymphocytes; Lymphocytes T; Malignancy; Medical prognosis; Metastases; Mice; Microenvironments; Original Research; Protein transport; Proteins; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Tumor Escape - genetics; Tumor Microenvironment - immunology; Tumors; HEPATOCELLULAR CARCINOMA; IMMUNE RESPONSE