Targeting Mitochondrial Biogenesis and Mitochondrial Substrate Utilization to Treat Obesity and Insulin Resistance, Respectively - Two Data-Driven Hypotheses

• Published in: Current diabetes reviews Vol. 13; no. 4; p. 395
• Main Authors: Hey-Mogensen, Martin, Clausen, Trine R
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2017
• Subjects: Animals; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Diabetes Mellitus, Type 2 - physiopathology; Energy Metabolism; Humans; Insulin Resistance; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial Turnover; Obesity - metabolism; Obesity - pathology; Obesity - physiopathology; Organelle Biogenesis; Signal Transduction; Obesity; biogenesis; type 2 diabetes; inhibiting substrate uptake; mitochondria

The mitochondrion plays a critical role in cellular energy metabolism. For this reason it is considered as a plausible target for the treatment of metabolic diseases such as obesity and type-2 diabetes. Although several mitochondrial molecular targets have been suggested and investigated, currently...