Preparation and Characterization of Silymarin Synchronized and Sustained Release Dropping Pill

• Published in: Current drug delivery Vol. 14; no. 5; p. 650
• Main Authors: Liu, Zhi-Hong, Li, Xue-Jing, Huang, Ai-Wen, Zhang, Jing, Song, Hong-Tao
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.08.2017
• Subjects: Administration, Oral; Animals; Biological Availability; Delayed-Action Preparations; Dogs; Drugs, Chinese Herbal - administration & dosage; Drugs, Chinese Herbal - pharmacokinetics; Silymarin - administration & dosage; Silymarin - pharmacokinetics; Solubility; silymarin; Bioavailability; synchronized release; solid dispersion technique; sustained release; dropping pills

This study aimed to develop a synchronized and sustained-release silymarin dropping pill, and to evaluate its pharmacokinetic characteristics. Polyoxyethylene stearate, glyceryl monostearate, and stearic acid were used to prepare the dropping pills. X-ray powder diffraction, differential scanning ca...