CircRNAs in Lung-intestinal Axis Cancer
The "exterior-interior relationship between the lung and the large intestine" is a basic theory in Traditional Chinese Medicine (TCM), which has been confirmed by mounting evidence, and the lung-intestinal axis can be seen as an extension of this theory. Circular RNAs (circRNAs) are a kind...
Saved in:
Published in | Current molecular medicine Vol. 21; no. 4; p. 291 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
01.01.2021
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | The "exterior-interior relationship between the lung and the large intestine" is a basic theory in Traditional Chinese Medicine (TCM), which has been confirmed by mounting evidence, and the lung-intestinal axis can be seen as an extension of this theory. Circular RNAs (circRNAs) are a kind of conserved and structurally stable noncoding RNAs, which have been found to be differentially expressed and associated with the development of cancer in malignant tumors. Many studies have found that circRNAs play an important role in lung and intestinal cancers. This review focuses on circRNAs and reveals that there are common circRNAs that are both highly or poorly expressed in lung-intestinal axis cancers and most of them regulate the proliferation, migration, and invasion of cancer cells by sponging miRNAs. These results not only provide new evidence and research ideas for the "exterior-interior relationship between the lung and the large intestine", but also suggest that circRNAs can be new potential therapeutic targets for the future drug research of lung-intestinal axis diseases. |
---|---|
AbstractList | The "exterior-interior relationship between the lung and the large intestine" is a basic theory in Traditional Chinese Medicine (TCM), which has been confirmed by mounting evidence, and the lung-intestinal axis can be seen as an extension of this theory. Circular RNAs (circRNAs) are a kind of conserved and structurally stable noncoding RNAs, which have been found to be differentially expressed and associated with the development of cancer in malignant tumors. Many studies have found that circRNAs play an important role in lung and intestinal cancers. This review focuses on circRNAs and reveals that there are common circRNAs that are both highly or poorly expressed in lung-intestinal axis cancers and most of them regulate the proliferation, migration, and invasion of cancer cells by sponging miRNAs. These results not only provide new evidence and research ideas for the "exterior-interior relationship between the lung and the large intestine", but also suggest that circRNAs can be new potential therapeutic targets for the future drug research of lung-intestinal axis diseases. |
Author | Li, Ning Ma, Jingjing Chen, Gang Li, Bingxin Wang, Chengmin Zhou, Di Feng, Yuan |
Author_xml | – sequence: 1 givenname: Chengmin surname: Wang fullname: Wang, Chengmin organization: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China – sequence: 2 givenname: Yuan surname: Feng fullname: Feng, Yuan organization: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China – sequence: 3 givenname: Bingxin surname: Li fullname: Li, Bingxin organization: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China – sequence: 4 givenname: Di surname: Zhou fullname: Zhou, Di organization: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China – sequence: 5 givenname: Jingjing surname: Ma fullname: Ma, Jingjing organization: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China – sequence: 6 givenname: Gang surname: Chen fullname: Chen, Gang organization: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China – sequence: 7 givenname: Ning surname: Li fullname: Li, Ning organization: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32867635$$D View this record in MEDLINE/PubMed |
BookMark | eNo1jstKAzEUQIMo2lZ_QcaVq2juvXkuh8EXDBVE1yXJJBJoY5mZgv69gro6iwOHs2TH9aMmxq5A3CAYeQtKa4VSoHDOoRCWABAR3BFbgDWK_3h9ys4IrTaa1IJdd2WML-t2akpt-kN956XOaZpL9dum_SxT0_ka03jOTrLfTunijyv2dn_32j3y_vnhqWt7HqQRM3cWVUBy2VtJguKAOdtkIBibBSn0FpJ00SUZIWZhQFsPYSDp0UiijCt2-dvdH8IuDZv9WHZ-_Nr8H-M3eCc_dQ |
CitedBy_id | crossref_primary_10_1016_j_ecoenv_2021_112637 crossref_primary_10_3389_fphar_2020_611060 |
ContentType | Journal Article |
Copyright | Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. |
Copyright_xml | – notice: Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. |
DBID | CGR CUY CVF ECM EIF NPM |
DOI | 10.2174/1566524020999200831122219 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
EISSN | 1875-5666 |
ExternalDocumentID | 32867635 |
Genre | Research Support, Non-U.S. Gov't Journal Article Review |
GroupedDBID | CGR CUY CVF ECM EIF NPM |
ID | FETCH-LOGICAL-b470t-9825b239fa84303cd2ff8e71b78f0352a81e49c9e4c1cf07168a1bd34a27433f2 |
IngestDate | Tue Jul 04 17:31:12 EDT 2023 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 4 |
Keywords | differential expression CircRNAs biomarker lung-intestinal exterior-interior relationship MiRNA lung-intestinal axis |
Language | English |
License | Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-b470t-9825b239fa84303cd2ff8e71b78f0352a81e49c9e4c1cf07168a1bd34a27433f2 |
PMID | 32867635 |
ParticipantIDs | pubmed_primary_32867635 |
PublicationCentury | 2000 |
PublicationDate | 2021-01-01 |
PublicationDateYYYYMMDD | 2021-01-01 |
PublicationDate_xml | – month: 01 year: 2021 text: 2021-01-01 day: 01 |
PublicationDecade | 2020 |
PublicationPlace | Netherlands |
PublicationPlace_xml | – name: Netherlands |
PublicationTitle | Current molecular medicine |
PublicationTitleAlternate | Curr Mol Med |
PublicationYear | 2021 |
Score | 2.3674068 |
SecondaryResourceType | review_article |
Snippet | The "exterior-interior relationship between the lung and the large intestine" is a basic theory in Traditional Chinese Medicine (TCM), which has been confirmed... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 291 |
SubjectTerms | Animals Gene Expression Regulation, Neoplastic Humans Intestinal Neoplasms - genetics Intestinal Neoplasms - pathology Lung Neoplasms - genetics Lung Neoplasms - pathology MicroRNAs - genetics RNA, Circular - genetics |
Title | CircRNAs in Lung-intestinal Axis Cancer |
URI | https://www.ncbi.nlm.nih.gov/pubmed/32867635 |
Volume | 21 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bS8MwFA6bwtiLKN5vVBB8kGgv2Zo8zqKMoUNkw-nLSNvE9WHdmBsMf70nabuV6vDyEkrSlqRfzul3kpNzEDpXmzucCYEZkGtMKHcwC8wQO6HkruP6PuE62me73uySVq_WK5VaOa-l2dS_Cj6-PVfyH1ShDnBVp2T_gOzipVAB14AvlIAwlL_C2IsmwVO7oV1a70FqsQr-ADKrGGZjHr1fegrTSZ6AZvGYhlla3C-768_pCrI3EPHbMFpMHhi5rn-Z5dx4tC_ADfz-5ssbXwejmVZlUX5JwbZySwoiUYNgxWAgevW8nkxOMqfzgeSVXpJvq6iMlbGj1gXgPTW1h6O4qK0zm1lAShJFmQNpPNQoOTatqyB5P7cW4mRnTWVUdqnSeO3Hhwo6SztyvbIbVVTJHi2YFppidDbRRmobGI0E6C1UEvE2ushANqLYKIBsKJCNBOQd1L277XhNnGa3wD5xzSlmYJv7tsMkpwR4RBDaUlLhWr5LpQpSy6klCAuYIIEVSGCCIFSWHzqE28D6HGnvorV4FIt9ZFhUhKwmzTBUARyp4JRRIIJmzQw52LP8AO0l4-qPkxAm_WzEhytbjlB1OTWO0boEmREnQMCm_qn-tp-_fCll |
link.rule.ids | 783 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=CircRNAs+in+Lung-intestinal+Axis+Cancer&rft.jtitle=Current+molecular+medicine&rft.au=Wang%2C+Chengmin&rft.au=Feng%2C+Yuan&rft.au=Li%2C+Bingxin&rft.au=Zhou%2C+Di&rft.date=2021-01-01&rft.eissn=1875-5666&rft.volume=21&rft.issue=4&rft.spage=291&rft_id=info:doi/10.2174%2F1566524020999200831122219&rft_id=info%3Apmid%2F32867635&rft_id=info%3Apmid%2F32867635&rft.externalDocID=32867635 |