Integrating Bioinformatics and Drug Sensitivity Analyses to Identify Molecular Characteristics Associated with Targeting Necroptosis in Breast Cancer and their Clinical Prognostic Significance

• Published in: Recent patents on anti-cancer drug discovery Vol. 19; no. 5; p. 681
• Main Authors: Zheng, Chang, Guo, Hanbin, Mo, Yongpan, Liu, Guowen
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2024
• Subjects: Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Computational Biology - methods; Female; Gene Expression Regulation, Neoplastic; Humans; Necroptosis - drug effects; Prognosis; survival prognosis analysis; integrated bioinformatics analysis; pathogenesis; drug sensitivity; Breast cancer; necroptosis

Breast cancer accounts for over 1.8 million new cases worldwide annually, and prompt diagnosis and treatment are imperative to prevent mortality. Necroptosis, a form of programmed cell death, is thought to be a critical pathway for cancer cell apoptosis, yet, its relationship with breast cancer prog...