The Effect of PEGylation on Drugs' Pharmacokinetic Parameters; from Absorption to Excretion

• Published in: Current drug delivery Vol. 21; no. 7; p. 978
• Main Authors: Khajeei, Ali, Masoomzadeh, Salar, Gholikhani, Tooba, Javadzadeh, Yousef
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2024
• Subjects: Animals; Drug Delivery Systems; Humans; Pharmaceutical Preparations - administration & dosage; Pharmaceutical Preparations - chemistry; Pharmaceutical Preparations - metabolism; Pharmacokinetics; Polyethylene Glycols - chemistry; metabolism; Absorption; PEG; PEGylation; drug delivery; pharmacokinetic

Until the drugs enter humans life, they may face problems in transportation, drug delivery, and metabolism. These problems can cause reducing drug's therapeutic effect and even increase its side effects. Together, these cases can reduce the patient's compliance with the treatment and compl...